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Urological Research

, Volume 40, Issue 3, pp 219–224 | Cite as

Role of combined use of potassium citrate and tamsulosin in the management of uric acid distal ureteral calculi

  • Osama El-Gamal
  • Mohamed El-BendaryEmail author
  • Maged Ragab
  • Mohamed Rasheed
Original Paper

Abstract

In this article, we investigated the effect of the combined use of tamsulosin and potassium citrate (Uralyt-U®) for the treatment of uric acid stones in the distal ureter. The study was designed as a prospective, double blind randomized controlled trial. A total of 191 adult patients with radiolucent distal ureteral calculi were recruited. We included patients with solitary stones ≥5 mm with mild or moderate hydronephrosis and a normal contralateral tract. The patients were randomized into four equal groups (the placebo, tamsulosin, Uralyt-U®, and the combined treatment groups). The patients were treated for a maximum duration of 4 weeks or until stone expulsion. The stone size in all groups ranged from 5 to 11 mm (7.69 ± 1.7 mm). The total expulsion rate of the stones was significantly lower in the control group (26.1%) compared with that of any of the other three groups (68.8, 58.7, and 84.8% respectively) (P < 0.05). Meanwhile, the difference between the Uralyt-U® group and the combined treatment group was also statistically significant (P < 0.05). When we studied the patients with stones >8 mm as a separate subgroup to find the effect of the used drugs on the relatively large stones, we detected that the expulsion rate of these stones was significantly higher in the patients who received the combined treatment in comparison with any of the other three groups (P < 0.05). In conclusion, the use of urinary alkalization with tamsulosin can increase the frequency of spontaneous passage of distal ureteral uric acid stones especially those of 8–11 mm.

Keywords

Ureter Calculi Uric acid Tamsulosin 

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Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • Osama El-Gamal
    • 1
  • Mohamed El-Bendary
    • 1
    Email author
  • Maged Ragab
    • 1
  • Mohamed Rasheed
    • 1
  1. 1.Department of UrologyTanta UniversityTantaEgypt

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