Urological Research

, Volume 39, Issue 5, pp 397–400 | Cite as

A comparative assessment of the clinical efficacy of intranasal desmopressin spray and diclofenac in the treatment of renal colic

  • Santosh KumarEmail author
  • Nimai Charan Behera
  • Debansu Sarkar
  • Seema Prasad
  • Arup Kumar Mandal
  • S. K. Singh
Original Paper


The aim of this study was to assess the efficacy of desmopressin nasal spray compared with diclofenac given intramuscularly in patients with acute renal colic caused by urolithiasis. The study included 72 patients randomized into three different groups: group A received desmopressin (40 mg, nasal spray), group B diclofenac (75 mg) intramuscularly and group C, both desmopressin and diclofenac. Pain was assessed using a visual analogue scale at baseline, 10, 30 min and 1 h after administering the treatments. Rescue analgesia was given at 30 min if needed. On admission, the pain level was the same in all three groups (group A 85; and group B and C 90 each). At 10 min the pain decreased minimally in all the groups but more in group B and C (group A 80 and group B and C 70 each). At 30 min pain scores were 75, 37.5 and 40 for group A, B and C, respectively, indicating that there was no significant pain relief in desmopressin group. Rescue analgesic had to be given to all patients in group A and two patients in group B and three patients in group C. Pain relief in the desmopressin only group was significantly less at 1 h even after rescue analgesia (pain scores of 27.5, 15 and 20 for group A, B and C respectively). Intranasal desmopressin is not an effective analgesic in renal colic: exerts mild analgesic effect over a period of 30 min. It does not potentiate the effect of diclofenac.


Renal colic Intranasal desmopressin Diclofenac 


  1. 1.
    Wein AJ, Kavoussi LR, Novick AC, Partin AW, Peters CA (2007) Campbell-Walsh urology, 9th edn. Elsevier, Philadelphia, p 1213Google Scholar
  2. 2.
    El-Sherif AE, Salem M, Yahia H, al-Sharkawy WA, al-Sayra M (1995) Treatment of renal colic by desmopressin intranasal spray and diclofenac sodium. J Urol 153:1395–1398PubMedCrossRefGoogle Scholar
  3. 3.
    Marumo F, Edelman IS (1971) Effect of Ca ++ and prostaglandin E1 on vasopressin activation of renal adenyl cyclase. J Clin Invest 50:1613–1620PubMedCrossRefGoogle Scholar
  4. 4.
    Grantham JJ, Orloff J (1968) Effect of prostaglandin E1 on the permeability response of the isolated collecting tubule to vasopressin, adenosine 3,5-monophosphate and theophylline. J Clin Invest 47:1154PubMedCrossRefGoogle Scholar
  5. 5.
    Grenabo L, Aurell M, Delin K, Holmlund D, Sjadin LG (1983) Antidiuretic hormone levels and the effect of indomethacin on ureteral colic. J Urol 129:941–943PubMedGoogle Scholar
  6. 6.
    Lopes T, Dias JS, Marchlero J (2001) An assessment of clinical efficacy of intranasal desmopressin spray in the treatment of renal colic. BJU Intern 87:322–325CrossRefGoogle Scholar
  7. 7.
    Seif SM, Zenser TV, Clarochi FF, Davis BB, Robinson AG (1978) DDAVP (1-desamino-8-arginine-vasopressin) treatment of central diabetes incipidus- mechanism of prolonged antidiauresis. J Clin Endocr Metab 46:381–388PubMedCrossRefGoogle Scholar
  8. 8.
    Rana BK, Shiina T, Insel PA (2001) Genetic variations and polymorphisms of G protein coupled receptors functional and therapeutic implications. Annu Rev Pharmacol Toxicol 41(2):593Google Scholar

Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • Santosh Kumar
    • 1
    Email author
  • Nimai Charan Behera
    • 1
  • Debansu Sarkar
    • 1
  • Seema Prasad
    • 2
  • Arup Kumar Mandal
    • 1
  • S. K. Singh
    • 1
  1. 1.Department of UrologyPGIMERChandigarhIndia
  2. 2.Department of AnesthesiaPGIMERChandigarhIndia

Personalised recommendations