Advertisement

Urological Research

, Volume 38, Issue 4, pp 321–326 | Cite as

Blood vessel rupture by cavitation

  • Hong Chen
  • Andrew A. Brayman
  • Michael R. Bailey
  • Thomas J. Matula
SYMPOSIUM PAPER

Abstract

Cavitation is thought to be one mechanism for vessel rupture during shock wave lithotripsy treatment. However, just how cavitation induces vessel rupture remains unknown. In this work, a high-speed photomicrography system was set up to directly observe the dynamics of bubbles inside blood vessels in ex vivo rat mesenteries. Vascular rupture correlating to observed bubble dynamics were examined by imaging bubble extravasation and dye leakage. The high-speed images show that bubble expansion can cause vessel distention, and bubble collapse can lead to vessel invagination. Liquid jets were also observed to form. Our results suggest that all three mechanisms, vessel distention, invagination and liquid jets, can contribute to vessel rupture.

Keywords

Cavitation Vessel rupture High-speed imaging 

Notes

Acknowledgments

Work supported by NIH grants EB000350, AR053652, DK043881 and DK070618.

References

  1. 1.
    Evan AP, Willis LR, Lingeman JE, McAteer JA (1998) Renal trauma and the risk of long-term complications in shock wave lithotripsy. Nephron 78:1–8CrossRefPubMedGoogle Scholar
  2. 2.
    Evan AP, Willis LR, McAteer JA, Bailey MR, Connors BA, Shao YZ, Lingeman JE, Williams JC, Fineberg NS, Crum LA (2002) Kidney damage and renal functional changes are minimized by waveform control that suppresses cavitation in shock wave lithotripsy. J Urol 168:1556–1562CrossRefPubMedGoogle Scholar
  3. 3.
    Rayleigh L (1917) On the pressure developed in a liquid during the collapse of a spherical cavity. Philos Mag Lett 34:94–98Google Scholar
  4. 4.
    Kodama T, Tomita Y (2000) Cavitation bubble behavior and bubble-shock wave interaction near a gelatin surface as a study of in vivo bubble dynamics. Appl Phys B: Lasers Opt 70:139–149CrossRefGoogle Scholar
  5. 5.
    Zhong P, Zhou YF, Zhu SL (2001) Dynamics of bubble oscillation in constrained media and mechanisms of vessel rupture in SWL. Ultrasound Med Biol 27:119–134CrossRefPubMedGoogle Scholar
  6. 6.
    Caskey CF, Stieger SM, Qin SP, Dayton PA, Ferrara KW (2007) Direct observations of ultrasound microbubble contrast agent interaction with the microvessel wall. J Acoust Soc Am 122:1191–1200CrossRefPubMedGoogle Scholar
  7. 7.
    Miller AP, Nanda NC (2004) Contrast echocardiography: new agents. Ultrasound Med Biol 30(4):425–434CrossRefPubMedGoogle Scholar
  8. 8.
    Qin SP, Caskey CF, Ferrara KW (2009) Ultrasound contrast microbubbles in imaging and therapy: physical principles and engineering. Phys Med Biol 54(6):R27–R57CrossRefPubMedGoogle Scholar
  9. 9.
    Blake JR, Gibson DC (1987) Cavitation bubbles near boundaries. Annu Rev Fluid Mech 19:99–123CrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Hong Chen
    • 1
  • Andrew A. Brayman
    • 1
  • Michael R. Bailey
    • 1
  • Thomas J. Matula
    • 1
  1. 1.Center for Industrial and Medical Ultrasound, Applied Physics LaboratoryUniversity of WashingtonSeattleUSA

Personalised recommendations