Urological Research

, Volume 37, Issue 4, pp 227–229 | Cite as

Ureteral stones due to systemic mastocytosis: diagnostic and therapeutic characteristics

  • Gerhard J. MolderingsEmail author
  • Gerold Solleder
  • Ulrich W. Kolck
  • Jürgen Homann
  • Detlev Schröder
  • Ivar von Kügelgen
  • Roland Vorreuther
Case Report


Urolithiasis is expected to cause a considerable complication in patients with systemic mastocytosis. The aim of the present report is to demonstrate that due to pathological activation and irritability of mast cells, special features in the diagnostic investigation and therapy of urolithiasis have to be considered in patients with systemic mastocytosis. The clinical presentation, diagnostic investigation and therapeutic procedure of urolithiasis in a patient with systemic mastocytosis are described. Urolithiasis may be a significant complication of systemic mastocytosis. Non-contrast CT is the main tool for diagnosing urolithiasis after a detailed history and clinical exam. Patients with systemic mastocytosis should receive a premedication composed of a glucocorticoid and H1- and H2-histamine receptor antagonists. An increased vulnerability of mucosal tissues is expected in patients with systemic mastocytosis that may limit the options of operative and postoperative therapy. Opioids should be used cautiously for analgesia in patients with systemic mastocytosis.


Urolithiasis Systemic mastocytosis Ureterorenoscopy Analgesia 


Conflict of interest statement

No competing financial interests exist.


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Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Gerhard J. Molderings
    • 1
    Email author
  • Gerold Solleder
    • 2
  • Ulrich W. Kolck
    • 3
  • Jürgen Homann
    • 3
  • Detlev Schröder
    • 4
  • Ivar von Kügelgen
    • 5
  • Roland Vorreuther
    • 2
  1. 1.Institute of Human GeneticsUniversity Hospital of BonnBonnGermany
  2. 2.Department of UrologyEvangelische Kliniken Bonn, WaldkrankenhausBonnGermany
  3. 3.Department for Internal MedicineEvangelische Kliniken Bonn, WaldkrankenhausBonnGermany
  4. 4.Department of SurgeryEvangelische Kliniken Bonn, WaldkrankenhausBonnGermany
  5. 5.Department of Pharmacology and ToxicologyUniversity of BonnBonnGermany

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