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Urological Research

, Volume 34, Issue 6, pp 365–372 | Cite as

Chinese herbal medicines and their efficacy in treating renal stones

  • Mayur Danny I. Gohel
  • Siu Ping Wong
Original Paper

Abstract

In herbal treatment of kidney stones, anti-lithics are used to “dissolve” the stones or aid their passing to guard against further retention. Diuretic action is also needed to increase the amount of fluid going through the kidneys and flush out the deposits. Previous clinical studies have shown that herbal medicines and their concoctions could be used to inhibit calcium oxalate crystallization. However, the pharmacodynamics and in-vitro effects of such medicines have not been established. Five Chinese herbal medicines were selected based on their usefulness in treating stone disease. A 96-well plate oxalate-induced turbidity in artificial urine was used to evaluate the efficacies of the different herbal medicines on calcium oxalate crystallization. The metastable limit was determined and the nucleation rate was derived from 12-min time-course measurement of turbidity at 405 nm. Phase-contrast microscopy was used to visualize the crystals. The results showed that with increasing concentrations of herbal extracts, smaller calcium oxalate crystal sizes were observed. Overall, the five herbal medicinal extracts tested were able to promote nucleation of calcium oxalate crystals while at the same time decreasing the size. This in-vitro crystallization confirms that prophylaxis of renal stones could be achieved by reducing overall supersaturation through promotion of small crystal nucleates and concomitant pharmacological diuretic action of herbal medicines. Clinical studies will provide more definitive conclusions.

Keywords

Chinese herbal medicines Urolithiasis Calcium oxalate Metastable limit Traditional Chinese medicine 

Notes

Acknowledgments

This work was supported in part by research grants (G-T070 and G-T455) from HKPU to MDIG. Mr K.P. Chan (Kwong Wah Hospital, HK) for magnesium and citrate analyses.

References

  1. 1.
    McNamara S, Ke SX (1995) Traditional Chinese medicine. Hamish Hamilton, London, UKGoogle Scholar
  2. 2.
    Reid DP (1999) Chinese herbal medicine. Shambala Publications Inc., Boston, USAGoogle Scholar
  3. 3.
    Ou M, Li YW (1994) The traditional Chinese drug and its usage. Hai Feng Publishing Company, Hong KongGoogle Scholar
  4. 4.
    Li PC, Poon MKT, Ko KM (1996) Schisandra chinensis-dependent myocardial protective action of Sheng-Mai-San in rats. Am J Chin Med 24:255–262PubMedCrossRefGoogle Scholar
  5. 5.
    Kou Q, Fang DY (1996) Therapeutic effects of the instant rheumatoid medicinal granules for treatment of acute rheumatoid arthritis. A report of 34 cases. J Tradit Chin Med 17:163–167Google Scholar
  6. 6.
    Tou SX, Zhou M (1998) A clinical study on Bing Gan Ling oral liquid for treatment of hepatitis C. J Tradit Chin Med 18:209–214Google Scholar
  7. 7.
    Hoffman H (1983) The new holistic herbs. In: Hoffman H (eds) The urinary system. Element Books Limited, UK, pp. 108–111Google Scholar
  8. 8.
    Koide T, Yamaguchi S, Utsunomiya M, Yoshioka T, Sugiyama K (1995) The inhibitory effect of kampo extracts on in vitro calcium oxalate crystallization and in vivo stone formation in an animal model. Int J Urol 2:81–86PubMedGoogle Scholar
  9. 9.
    Hirayama H, Wang Z, Nishi K, Ogawa A, Ishimatu T, Ueda S, Kubo T, Nohara T (1993) Effect of Desmodium styracifolium-triterpenoid on calcium oxalate renal stones. Br J Urol 71:143–147PubMedCrossRefGoogle Scholar
  10. 10.
    Yasui T, Fujita K, Sato M, Sugimoto M, Iguchi M, Nomura S, Kohri K (1999) The effect of takusha, a kampo medicine, on renal stone formation and osteopontin expression in a rat urolithiasis model. Urol Res 27:194–199PubMedCrossRefGoogle Scholar
  11. 11.
    Atmani F, Khan SR (2000) Effects of an extract from Herniaria hirsuta on calcium oxalate crystallization in vitro. BJU Int 85:621–625PubMedCrossRefGoogle Scholar
  12. 12.
    Grases F, Ramis M, Costa-Bauza A, March JG (1995) Effect of Herniaria hirsuta and Agropyron repens on calcium oxalate urolithiasis risk in rats. J Ethnopharmacol 45:211–214PubMedCrossRefGoogle Scholar
  13. 13.
    http://www.tcmtreatment.com. Cited 4 Sept. 2006Google Scholar
  14. 14.
    Zhao Z (2004) An illustrated Chinese Materia Medica in Hong Kong. School of Chinese Medicine, Hong Kong Baptist University, Hong KongGoogle Scholar
  15. 15.
    Chen JK, Chen TT (2004) Chinese medical herbology and pharmacology. The Art of Medicine Press Inc., California, USAGoogle Scholar
  16. 16.
    http://www.info.gov.hk/dh/main_ser/index.htm. Cited 4 Sept. 2006Google Scholar
  17. 17.
    Kavanagh JP, Jones L, Rao PN (2000) Calcium oxalate crystallization kinetics studied by oxalate-induced turbidity in fresh human urine and artificial urine. Clin Sci 98:151–158PubMedCrossRefGoogle Scholar
  18. 18.
    Kavanagh JP, Jones L, Rao PN (1999) Calcium oxalate crystallization kinetics at different concentrations of human and artificial urine, with a constant calcium to oxalate ratio. Urol Res 27:231–237PubMedCrossRefGoogle Scholar
  19. 19.
    Holmes RP, Kennedy M (2000) Estimation of the oxalate content of foods and daily oxalate intake. Kidney Int 57:1662–1667PubMedCrossRefGoogle Scholar
  20. 20.
    Baumann JM, Affolter B, Brenneisen J, Siegrist HP (1997) Measurement of metastability, growth and aggregation of calcium oxalate in native urine—a new approach for clinical and experimental stone research. Urol Int 59:214–220PubMedCrossRefGoogle Scholar
  21. 21.
    Kaufman DW, Kelly JP, Rosenberg L, Anderson TE, Mitchell AA (2002) Recent patterns of medication use in the ambulatory adult population of the United States: the Slone survey. J Am Med Assoc 287:337–344CrossRefGoogle Scholar
  22. 22.
    Yun TK (1999) Update from Asia: Asian studies on cancer chemoprevention. Ann NY Acad Sci 889:157–192PubMedCrossRefGoogle Scholar
  23. 23.
    Yuen JWM, Gohel MDI (2005) Anticancer effects of Ganoderma lucidum: a review of scientific evidence. Nutr Cancer 53:11–17PubMedCrossRefGoogle Scholar
  24. 24.
    http://www.cmchk.org.hk/eindex.htm. Cited 4 Sept. 2006Google Scholar
  25. 25.
    http://alternativehealing.org/traditional_chinese_medicine.htm. Cited 4 Sept. 2006Google Scholar
  26. 26.
    Gohel MDI, Shum DKY, Li MK (1994) Crystallization of urinary calcium oxalate at standardized osmolality and pH in the frozen state. Clin Chim Acta 231:11–22PubMedCrossRefGoogle Scholar
  27. 27.
    Roehrborn CG, Schneider HJ, Rugendorff EW (1986) Determination of stone-forming risk by measuring crystal formation in whole urine with gel model. Urology 27:531–536PubMedCrossRefGoogle Scholar
  28. 28.
    Li MK, Shum DKY, Choi S (1987) Detection of crystallization inhibitory activity of whole urine with a gel model. Urol Res 15:75–77PubMedCrossRefGoogle Scholar
  29. 29.
    Hess B, Meinhardt U, Zipperle L, Giovanoli R, Jaeger P (1995) Simultaneous measurements of calcium oxalate crystal nucleation and aggregation: impact of various modifiers. Urol Res 23:231–238PubMedCrossRefGoogle Scholar
  30. 30.
    Kok DJ (1997) Intratubular crystallization events. World J Urol 15:219–228PubMedCrossRefGoogle Scholar
  31. 31.
    Brenner BM (2004) The kidney, 7th edn. In: Brenner BM, Rector FC Jr (eds) Saunders, Philadelphia, USAGoogle Scholar

Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  1. 1.Department of Health Technology and InformaticsThe Hong Kong Polytechnic University, Hung HomKowloonHong Kong

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