Amino Acids in Life: A Prebiotic Division of Labor
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There are more than 20 amino acids used in Biology, and their utilization is enigmatic. Here, I propose that there was a prebiotic division of labor between two subsets of amino acids. The first set is the alpha-l set, which includes all the genetically encoded amino acids. These convey heritable information. The second set is all the remaining types, which includes the d-enantiomers incorporated in non-ribosomally encoded peptides and those used in signaling. These convey proximally mediated information about the environment. This division of labor became fixed early in the evolutionary history of life on the Earth.
KeywordsAmino acids Prebiotic chemistry Isomers Signals
- Miller SL, Orgel LE (1974) The origins of life on the earth. Prentice Hall, Englewood CliffsGoogle Scholar
- Peirce CS (1909) A letter to William James. In: Peirce Edition Project (ed) The essential Peirce, vol 2. Indiana University Press, Bloomington, pp 492–502Google Scholar
- Wolosker H, Dumin E, Balan L, Foltyn VN (2008) d-amino acids in the brain: d-serine in neurotransmission and neurodegeneration. FEBS 275:3126–3514Google Scholar