Journal of Molecular Evolution

, Volume 80, Issue 2, pp 86–97

Salt-Promoted Synthesis of RNA-like Molecules in Simulated Hydrothermal Conditions

Original Article

Abstract

A fundamental problem in origins of life research is how the first polymers with the properties of nucleic acids were synthesized and incorporated into living systems on the prebiotic Earth. Here, we show that RNA-like polymers can be synthesized non-enzymatically from 5′-phosphate mononucleosides in salty environments. The polymers were identified and analyzed by gel electrophoresis, nanopore analysis, UV spectra, and action of RNases. The synthesis of phosphodiester bonds is driven by the chemical potential made available in the fluctuating hydrated and anhydrous conditions of hydrothermal fields associated with volcanic land masses.

Keywords

RNA synthesis Hydrothermal fields RNA world 

Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.UMR 7205-ISyEB, CNRS-MNHN-UPMCParisFrance
  2. 2.Department of Biomolecular EngineeringUniversity of CaliforniaSanta CruzUSA

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