Journal of Molecular Evolution

, Volume 77, Issue 3, pp 119–129 | Cite as

Lineage-Specific Duplications of Muroidea Faim and Spag6 Genes and Atypical Accelerated Evolution of the Parental Spag6 Gene

  • Huan Qiu
  • Aniela Gołas
  • Paweł Grzmil
  • Leszek Wojnowski
Original Article
First Online:
Received:
Accepted:

Abstract

Gene duplications restricted to single lineage combined with an asymmetric evolution of the resulting genes may play particularly important roles in this lineage’s biology. We searched and identified asymmetrical evolution in nine gene families that duplicated exclusively in rodents and are present as single-copies in human, dog, cow, elephant, opossum, chicken, lizard, and Western clawed frog. Among those nine gene families are Fas apoptosis inhibitory molecule (Faim), implicated in apoptosis, and Sperm antigen 6 (Spag6), implicated in sperm mobility. Both genes were duplicated in or before the Muroidea ancestor. Due to the highly asymmetric evolution of the resulting paralogs, the existence of these duplications had been previously overlooked. Interestingly, Spag6, previously regarded and characterized as a single-copy ortholog of human Spag6, turns out to be a Muroidea-specific paralog. Conversely, the newly identified, highly divergent Spag6-BC061194 is in fact the parental gene. In consequence, this gene represents a rare exception from the general rule of rapid evolution of derived rather than parental genes following gene duplication. Unusual genes such as murine Spag6 may help to understand which mechanisms are responsible for this rule.

Keywords

Gene duplication Asymmetric evolution Faim Spag6 Positive selection 
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Notes

Acknowledgments

This study was partly supported by Jagiellonian University, Institute of Zoology Grant (K/ZDS/003254). We acknowledge the release and sharing of whole-genome sequences of guinea pig, squirrel, rabbit and elephant prior to publication by the Broad Institute, Cambridge, MA, USA. We thank the editor and the two anonymous reviewers for constructive suggestions for improving the paper.

Conflict of interest

The authors declare that they have no conflict of interest.

Supplementary material

239_2013_9585_MOESM1_ESM.docx (1.6 mb)
Supplementary material 1 (DOCX 1,665 kb)

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Huan Qiu
    • 1
    • 3
  • Aniela Gołas
    • 2
  • Paweł Grzmil
    • 2
  • Leszek Wojnowski
    • 1
  1. 1.Department of PharmacologyUniversity Medical Center of the Johannes Gutenberg University MainzMainzGermany
  2. 2.Department of Genetics and Evolution, Institute of ZoologyJagiellonian UniversityKrakówPoland
  3. 3.Department of Ecology, Evolution and Natural ResourcesRutgers UniversityNew BrunswickUSA

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