Journal of Molecular Evolution

, Volume 71, Issue 1, pp 3–5

The Origin of Modern 5S rRNA: A Case of Relating Models of Structural History to Phylogenetic Data



Evolutionary models of molecular structures must incorporate molecular information at different levels of structural complexity and must be phrased within a phylogenetic perspective. In this regard, phylogenetic trees of substructures that are reconstructed from molecular features that contribute to order and thermodynamic stability show that a gradual model of evolution of 5S rRNA structure is more parsimonious than models that invoke large segmental duplications of the molecule. The search for trees of substructures that are most parsimonious, by their very nature, defines an objective strategy to select models of molecular change that best fit structural data. When combined with additional data, such as the age of protein domains that interact with RNA substructures, these trees can be used to falsify unlikely hypotheses.


5S rRNA origin Inverse duplication Molecular evolution Phylogenetics RNA structure 

Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.Department of Crop SciencesUniversity of Illinois at Urbana-ChampaignUrbanaUSA
  2. 2.Laboratory of Molecular Epigenetics of the Ministry of Education, School of Life SciencesNortheast Normal UniversityChangchunPeople’s Republic of China
  3. 3.W.M. Keck Center for Comparative and Functional Genomics, Roy J. Carver Biotechnology CenterUniversity of IllinoisUrbanaUSA

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