A Comparison Among the Models Proposed to Explain the Origin of the tRNA Molecule: A Synthesis
A comparison is made among all the models proposed to explain the origin of the tRNA molecule. The conclusion reached is that, for the model predicting that the tRNA molecule originated after the assembly of two hairpin-like structures, molecular fossils have been found in the half-genes of the tRNAs of Nanoarchaeum equitans. These might be the witnesses of the transition stage predicted by the model through which the evolution of the tRNA molecule passed, thus providing considerable corroboration for this model.
KeywordsCorroboration/falsification of theories Transition stages Molecular fossils of genes Ancestral stages Missing link Hairpin structure
- Di Giulio M (2008b) Split genes, ancestral genes. In: Tze-Fei Wong J, Lazcano A (eds) Prebiotic evolution and astrobiology, chap 13. Landes Bioscience, Austin, TXGoogle Scholar
- Maizels N, Weiner AM (1993) The genomic tag hypothesis: modern viruses as molecular fossils of ancient strategies for genomic replication. In: Gesteland RF, Atkins JF (eds) The RNA world. Cold Spring Harbor Laboratory Press, Plainview, NY, pp 577–602Google Scholar
- Tanaka T, Kikuchi Y (2001) Origin of cloverleaf of transfer RNA—the double-hairpin model: implication for the role of tRNA intron and the long extra loop. Viva Origino 29:134–142Google Scholar
- Woese CR (1969) The biological significance of the genetic code. Prog Mol Subcell Biol 1:5–46Google Scholar