Journal of Molecular Evolution

, Volume 68, Issue 6, pp 700–705 | Cite as

In Silico Prediction of Two Classes of Honeybee Genes with CpG Deficiency or CpG Enrichment and Sorting According to Gene Ontology Classes

Article

Abstract

Two honeybee DNA methyltransferase genes have recently been identified and confirmed to be functional. The honeybee genes under regulation by DNA methylation may therefore be CpG deficient, due to natural deamination of methylated DNA. In this report, we show that <39% of the known honeybee genes are likely to be methylated on the basis of their low CpG obs/exp ratios. In contrast, orthologues of these genes in the fruitfly do not show CpG deficiency. Classes of function as determined by Gene Ontology were obtained for the honeybee genes with significantly low and high CpG obs/exp ratios. Overrepresented classes in the low CpG[obs/exp] genes are involved in transcription, translation, protein folding, protein localization, protein transportation, cell cycle, and DNA and RNA metabolism.

Keywords

Honeybee DNA methylation Gene Ontology classes CpG deficiency 

Notes

Acknowledgments

We thank two anonymous reviewers for helpful comments. We are grateful to Dr. Michael Santos and Dr. Shawn Arellano for critical reading of the manuscript.

Supplementary material

239_2009_9244_MOESM1_ESM.pdf (191 kb)
MOSESM1 (PDF 190 kb)

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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  1. 1.School of Biological Sciences and Genome Research CentreThe University of Hong KongPokfulam, Hong KongChina

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