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Journal of Molecular Evolution

, Volume 65, Issue 6, pp 725–729 | Cite as

Plastid Isoprenoid Metabolism in the Oyster Parasite Perkinsus marinus Connects Dinoflagellates and Malaria Pathogens—New Impetus for Studying Alveolates

  • Carina Grauvogel
  • Kimberly S. Reece
  • Henner Brinkmann
  • Jörn PetersenEmail author
Letter to the Editor

The capacity for isopentenyl pyrophosphate (IPP) synthesis, the common precursor of isoprenoids, is universally distributed among photosynthetic and heterotrophic eukaryotes (Lange et al. 2000; this study). Land plants harbor two unrelated metabolic routes with specific substrates, intermediates, and sets of enzymes (Grauvogel and Petersen 2007). The cytosolic mevalonate-dependent MVA pathway, which is also present in metazoa and fungi, has been known since the 1960s (Katsuki and Bloch 1967; Lynen 1967), whereas the plastidial MEP (2-C-methyl-d-erythritol 4-phosphate) pathway was discovered just 10 years ago (Rohmer et al. 1993; Lichtenthaler et al. 1997). Plastid IPP generation was inherited from the cyanobacterial endosymbiont and subsequently spread to complex algae and Apicomplexa (e.g., Plasmodium falciparum) via eukaryote-to-eukaryote endosymbioses (Delwiche 1999). The “raison d’être” for plastids in heterotrophic parasites is their indispensable metabolic capacity, and the...

Keywords

Fosmidomycin Isopentenyl Pyrophosphate Secondary Endosymbiosis Endosymbiotic Gene Transfer Isoprenoid Metabolism 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

We thank Ulrike Brandt (Braunschweig) for excellent technical assistance, René Teich for practical assistance, and William Martin (Düsseldorf) for helpful comments on the manuscript. Preliminary sequence data of Perkinsus marinus were obtained from The Institute for Genomic Research through the Web site at http://www.tigr.org, and sequencing was accomplished with support from the National Science Foundation. Major financial support, including a Ph.D. stipend for C.G., was received from the Deutsche Forschungsgemeinschaft (CE 1/27-2). This is VIMS contribution number 2871. The authors also want to thank two anonymous reviewers for careful reading and constructive criticism of the manuscript.

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Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Carina Grauvogel
    • 1
  • Kimberly S. Reece
    • 2
  • Henner Brinkmann
    • 3
  • Jörn Petersen
    • 1
    • 4
    Email author
  1. 1.Institut für GenetikTechnische Universität BraunschweigBraunschweigGermany
  2. 2.Virginia Institute of Marine ScienceThe College of William and MaryGloucester PointUSA
  3. 3.Centre Robert Cedergren, Département de BiochimieUniversité de MontréalMontréalCanada
  4. 4.DSMZ-Deutsche Sammlung für Mikroorganismen und Zellkulturen GmbHBraunschweigGermany

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