Journal of Molecular Evolution

, Volume 63, Issue 5, pp 691–706

Ancient Phylogenetic Beginnings of Immunoglobulin Hypermutation

  • Jaroslav Kubrycht
  • Karel Sigler
  • Michal Růžička
  • Pavel Souček
  • Jiří Borecký
  • Petr Ježek
Article

Abstract

Many structures and molecules closely related to those involved in the specific process of immunoglobulin (Ig) hypermutation existed before the appearance of primordial Ig genes. Consequently, these structures can be found even in animals and organisms distinct from vertebrates; likewise, homologues of hypermutation enzymes are present in a broad range of species, from bacteria to mammals. Our analysis, based predominantly on primary structure, demonstrates the existence of molecules similar to Ig domains, variable Ig domains (IGv), and antigen receptors (AR) in unicellular organisms, nonvertebrate metazoans, and nonvertebrate Coelomata, respectively. In addition, we deal here with some important structural properties of CDR1-like segments of the selected sponge adhesion molecule GCSAMS exhibiting chimerical Ig domain similarities, and demonstrate the occurrence of conserved regions corresponding to Ohno’s modern intact primordial building block in the C-terminal part of IGv-related segments of nonvertebrate origin. The results of our analysis are also discussed with respect to the possible phylogeny of molecules preceding the hypothetical common antigen receptor ancestor.

Keywords

BLAST CDR1 Domain similarity Geodia cydonium Hypermutation Immunoglobulin Primordial building block Protein kinase substrate Template 

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Copyright information

© Springer Science+Business Media, Inc. 2006

Authors and Affiliations

  • Jaroslav Kubrycht
    • 1
  • Karel Sigler
    • 2
  • Michal Růžička
    • 3
  • Pavel Souček
    • 1
  • Jiří Borecký
    • 4
  • Petr Ježek
    • 3
  1. 1.Center of Occupational MedicineNational Institute of Public HealthPragueCzech Republic
  2. 2.Institute of MicrobiologyAcademy of Sciences of the Czech RepublicPragueCzech Republic
  3. 3.Institute of PhysiologyAcademy of Sciences of the Czech RepublicPragueCzech Republic
  4. 4.Centro de Biologia Molecular e EngenhariaUniversidade Estadual de CampinasSão Paulo

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