Journal of Molecular Evolution

, Volume 59, Issue 1, pp 20–30 | Cite as

A Plant Orthologue of RNase L Inhibitor (RLI) Is Induced in Plants Showing RNA Interference

  • Antonio Sergio Kimus Braz
  • Jean Finnegan
  • Peter Waterhouse
  • Rogério Margis


RNase L inhibitors (RLIs) correspond to a group of soluble proteins from the large ATP binding cassette (ABC) family of proteins. Structurally, RLIs have an N-terminal Fe–S domain and two nucleotide binding domains. Orthologous RLI sequences with more than 48% identity have been found from Archea to Eukaryota, but have not as yet been identified in Eubacteria. Some organisms, like Arabidopsis thaliana and human, have paralogous genes with differential expression patterns, the function of which remains to be determined. Expression of Arabidopsis RLI2 was slightly increased in transgenic plants showing RNA interference, suggesting a role in this pathway


RNase L inhibitor RNAi PTGS RNA silencing 



The authors want to thank FAPESP for accessing the SUCEST data bank. A.S.K. Braz was supported by a doctoral fellowship and R. Margis by a postdoctoral fellowship from Conselho Nacional de Desenvolvimento Científico e Tecnológico—CNPq.


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Copyright information

© Springer-Verlag 2004

Authors and Affiliations

  • Antonio Sergio Kimus Braz
    • 1
  • Jean Finnegan
    • 3
  • Peter Waterhouse
    • 3
  • Rogério Margis
    • 1
    • 2
  1. 1.LGMV—Laboratório de Genética Molecular Vegetal, Departamento de Genética, Instituto de Biologia, CCSUniversidade Federal do Rio JaneiroIlha do FundãoBrasil
  2. 2.Departamento de BioquímicaInstituto de QuímicaUFRJBrasil
  3. 3.Plant IndustryCSIRO, CanberraAustralia

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