Journal of Molecular Evolution

, Volume 57, Issue 3, pp 255–260 | Cite as

Structure-Based Phylogenies of the Serine β-Lactamases

  • Barry G. HallEmail author
  • Miriam Barlow


The serine β-lactamases present a special problem for phylogenetics because they have diverged so much that they fall into three classes that share no detectable sequence homology among themselves. Here we offer a solution to the problem in the form of two phylogenies that are based on a protein structure alignment. In the first, structural alignments were used as a guide for aligning amino acid sequences and in the second, the average root mean square distances between the alpha carbons of the proteins were used to create a pairwise distance matrix from which a neighbor-joining phylogeny was created. From those phylogenies, we show that the Class A and Class D β-lactamases are sister taxa and that the divergence of the Class C β-lactamases predated the divergence of the Class A and Class D β-lactamases.


Protein structure Bayesian phylogeny β-Lactamases 



This study was supported by Grant GM60761 from the National Institutes of Health. We are grateful to Reviewer 1 for insightful comments on an earlier version of this paper.


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Copyright information

© Springer-Verlag New York Inc. 2003

Authors and Affiliations

  1. 1.Biology Department, Hutchison HallUniversity of Rochester, Rochester, NY 14627-0211USA

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