Journal of Molecular Evolution

, Volume 57, Issue 3, pp 249–254 | Cite as

The Metallo-β-Lactamases Fall into Two Distinct Phylogenetic Groups

  • Barry G. HallEmail author
  • Stephen J. Salipante
  • Miriam Barlow


The Ambler Class B metallo-β-lactamases fall into two distinct phylogenetic groups based on the observation that there is no significant sequence homology between the sequences of members of different groups. Structural alignments confirm that those groups are no more closely related to each other than are the three classes of serine β-lactamases, Classes A, C, and D. We present phylogenies of these two groups and suggest a new classification scheme for the β-lactamases.


Metallo-β-lactamases Ambler Class B Serine β-lactamases 



This study was supported by Grant GM60761 from the National Institutes of Health.


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Copyright information

© Springer-Verlag New York Inc. 2003

Authors and Affiliations

  • Barry G. Hall
    • 1
    Email author
  • Stephen J. Salipante
    • 1
  • Miriam Barlow
    • 1
  1. 1.Biology Department, Hutchison HallUniversity of Rochester, Rochester, NY 14627-0211USA

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