Journal of Molecular Evolution

, Volume 57, Supplement 1, pp S148–S153 | Cite as

Inventing a Sex-Specific Gene: A Conserved Role of DMRT1 in Teleost Fishes Plus a Recent Duplication in the Medaka Oryzias latipes Resulted in DMY

  • Georges Lutfalla
  • Hugues Roest Crollius
  • Frédéric G. Brunet
  • Vincent Laudet
  • Marc Robinson-Rechavi
Article

Abstract

DMY, the first sex-determining gene to be described in a nonmammal vertebrate was recently characterized in the medaka fish (Oryziaslatipes). It is homologous to DMRT1, a conserved gene of the sex determination cascade in vertebrates. We have checked the near complete genomes of two other percomorph fishes, Tetraodonnigroviridis and Takifugurubripes, for supplementary homologs of DMRT1 and DMY. We also compared the new gene, DMY, to its homolog DMRT1 from all available vertebrates. Finally, we found evidence for sex-specific expression and alternative splicing of the homolog from T. nigroviridis. Our results show that DMY is a recent duplicate of DMRT1 in the medaka. Its role in sex determination was not acquired through an acceleration of evolutionary rates, but by translocation to the Y chromosome and possibly changes at key positions.

Keywords

Teleost fish Oryzias latipes DMY gene DMRT1 gene 

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Copyright information

© Springer-Verlag New York LLC 2003

Authors and Affiliations

  • Georges Lutfalla
    • 1
  • Hugues Roest Crollius
    • 2
  • Frédéric G. Brunet
    • 2
    • 3
  • Vincent Laudet
    • 3
  • Marc Robinson-Rechavi
    • 3
  1. 1.Défenses Antivirales et AntitumoralesUMR CNRS 5124, 1919, Route de Mende, 34293 Montpellier Cedex 5France
  2. 2.GenoscopeUMR CNRS 8030, 2, rue Gaston Crémieux, CP 5706, 91057 Evry CedexFrance
  3. 3.Laboratoire de Biologie Moléculaire et CellulaireEcole Normale Supérieure de Lyon, UMR CNRS 5665, 46 allée d’Italie, 69364 Lyon Cedex 07France

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