Advertisement

Journal of Molecular Evolution

, Volume 56, Issue 2, pp 169–174 | Cite as

Evolutionary Dynamics of Large Numts in the Human Genome: Rarity of Independent Insertions and Abundance of Post-Insertion Duplications

  • Einat Hazkani-Covo
  • Rotem Sorek
  • Dan Graur

Abstract

We determined the phylogenetic positions of 82 large nuclear pseudogenes of mitochondrial origin (numts) within the human genome. For each numt, two possibilities pertaining to its origin were considered: (1) independent insertion from the mitochondria into the nucleus, or (2) genomic duplication subsequent to the insertion. A significant increase in the rate of numt accumulation is seen after the divergence of Platyrrhini (New World monkeys) from the Catarrhini (Old World monkeys, apes and humans). By using pairwise phylogenetic analyses, we were able to demonstrate that this peak in numt accumulation is mostly the result of duplication of preexisting nuclear numts rather than the result of an increase in mitochondrial-sequence insertion. In fact, only about a third of all the numt repertoire in the human nuclear genome is due to insertions of mitochondrial sequences, the rest originated as duplications of preexisting numts. Hence, we conclude that numt insertion occurs at a much lower rate than previously reported. As expected under the assumption that genomic duplications occur at rates that are uninfluenced by content, older numts were found to be duplicated more times than recently inserted ones.

Numts Human genome Promiscuous DNA Gene duplicaton Pseudogenes Primates 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Copyright information

© Springer-Verlag New York Inc. 2003

Authors and Affiliations

  • Einat Hazkani-Covo
    • 1
  • Rotem Sorek
    • 1
  • Dan Graur
    • 1
  1. 1., Tel Aviv University, 69978, Ramat Aviv, Israel

Personalised recommendations