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Regulatory, ethical, and technical considerations on regenerative technologies and adipose-derived mesenchymal stem cells

  • Michele L. ZocchiEmail author
  • Vincenzo Vindigni
  • Andrea Pagani
  • Ortensia Pirro
  • Giamaica Conti
  • Andrea Sbarbati
  • Franco Bassetto
Master Class in Plastic Surgery
  • 33 Downloads

Abstract

Since the early days of molecular biology, organ and tissue regeneration represents a challenging medical goal. However, only recently the advances in the understanding of the cellular components have enabled the promise to become a reality. In this vast panorama of new technologies, stem cells have progressively established themselves as the most effective and user-friendly regenerative therapeutic tool. Scientific meetings, workshops, conferences, and forums focused on translational science of regenerative technologies are today blooming all over the world. The audience questions and, even more, the very often controversial and conflicting explanations highlight the great deal of confusion regarding this new discipline that should be considered today a real independent medical specialty, requiring long-term studies and dedication. All the technologies able to separate and concentrate the adipose tissue (AT) and the stromal vascular fraction (SVF) and their related clinical applications need to comply with a complex but still unclear regulatory frame, becoming everyday more severe and restrictive, this limiting their practical use. The aim of this manuscript is to overview the current status of the regulatory frame and few related ethical considerations and to describe the evolution in the way the adipose-derived stromal vascular fraction (SVF) is isolated, extracted, and concentrated, as well as, of the ongoing researches and related future perspectives. Considerations on the most controversial and still unclear points related to the regenerative medicine and surgery, seen from the perspective of a research group who dedicated their entire professional life to this field, are also provided.

Level of evidence: Not ratable.

Keywords

Regeneration Cell derivates PRP Adipose tissue (AT) Stromal vascular fraction (SVF) Mesenchymal stem cells (MSCs) Pericytes Growth factors (GFs) Minimal-grade manipulation (MGM) High-grade manipulation (HGM) Lipocondensation Sonication Bioactive composite grafts (BACG) Biocatalyzers MUSE cells Exosomes Photobiomodulation Acellular adipose matrix (AAM) 

Notes

Compliance with ethical standards

Funding information

No funds have been received.

Conflict of interest

Michele L. Zocchi, Vincenzo Vindigni, Andrea Pagani, Ortensia Pirr, Giamaica Contio, Andrea Sbarbati, and Franco Bassetto declare that they have no conflict of interest.

Ethical approval

No need of any ethical approval because the topic of the article is mainly related to basic science behind regenerative surgery and no direct action on patients has been taken and referred in the article.

Informed consent

For the abovementioned reasons, no informed consent has been necessary.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.C.S.M. Institute for Regenerative SurgeryTurinItaly
  2. 2.Institute of Plastic and Reconstructive Surgery of the University of PaduaPaduaItaly
  3. 3.Institute of Human AnatomyUniversity of VeronaVeronaItaly

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