The effect of TopClosure® TRS in the treatment of large abdominal wall defect
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Large abdominal wall defects, which are not suitable for primary closure partly due to the expected high tension closure and the considerable rate of recurrence, represent a substantial reconstructive challenge. The study is aimed to evaluate the clinical value of TopClosure® Tension-Relief System (TRS) in the treatment of large abdominal wall defect.
Thirteen patients with large abdominal wall defect were treated using TopClosure® TRS, and the average healing time, patients’ satisfaction, and complication were recorded.
After being treated with TopClosure® TRS, 10 cases were primary healing, three-case second-intention healing due to the thickened abdominal wall with mild scar. The average healing time and hospitalization time are shortened, while the primary healing rate and VAS satisfactory value improved. Logistic regression analyses indicated that age, BMI, defect area, wound infection, and diabetes may influence the effect of TopClosure® TRS in the repair of large abdominal wall defect.
Large abdominal wall defect can be treated using TopClosure® TRS, effectively and easily, which can be generalized to be used in clinics.
Level of evidence: Level IV, therapeutic study.
KeywordsLarge abdominal wall defect TopClosure® Tension-Relief System Primary healing
Compliance with ethical standards
Conflicts of interest
Xiaoli Wang, Zhanyong Zhu, Yueqiang Zhao, Mosheng Yu, and Moris Topaz declare that they have no conflicts of interest to disclose. Moris Topaz is one of the inventors of TopClosure® TRS ad CEO of IVT Medical Ltd. manufacturer of the device.
An ethical committee approval for the above reported procedure was waived by the Medical Ethics Committee of the Renmin Hospital of Wuhan University Review Board (2018-C007).
Following a detailed review of the intended surgical procedure, the patients consented for the publication of this study and the use medical information for the purposes of the study.
This work was supported by the Guiding Foundation of Renmin Hospital of Wuhan University (Grant No. RMYD2018M12).
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