Advertisement

European Journal of Plastic Surgery

, Volume 35, Issue 7, pp 557–560 | Cite as

Rare locations of multiple symmetric lipomatosis (Madelung’s disease)

  • Vincenzo PennaEmail author
  • Niklas Iblher
  • Jamil Al Jamali
  • G. Bjöern Stark
  • Gunther Felmerer
Case Report

Introduction

Multiple symmetric lipomatosis (MSL) is a rare disease of unknown etiology, which is characterized by the presence of massive symmetric deposits of unencapsulated fatty deposits around the face, back of the head, neck, upper arms, abdomen, back, and upper leg in a very specific distribution pattern giving the patients a “Michelin Man” resemblance [1, 2]. Because of this characteristic and the absolute symmetry, the condition is often dismissed as simple obesity. The condition often develops over a period of months to years. It is characterized by a steady increase in weight, despite all attempts at dieting, which often leads to the judgment of “a noncompliant patient.” MSL typically affects male patients from the Mediterranean countries aged 30–60 years. The etiology is still not clear, but a history of alcohol abuse is commonly found [2]. Some reports describe autosomal recessive or autosomal dominant inheritance [3, 4], and the association with mitochondrial dysfunction...

Keywords

Facial Nerve Lipomatosis Atypical Location Parotid Region Facial Nerve Involvement 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Civelek B, Celebioglu S, Ozpolat B (2006) An unusual entity for a plastic surgeon: Madelung syndrome. Plast Reconstr Surg 117(2):693–695PubMedCrossRefGoogle Scholar
  2. 2.
    Uglesic V et al (2004) Madelung syndrome (benign lipomatosis): clinical course and treatment. Scand J Plast Reconstr Surg Hand Surg 38(4):240–243PubMedCrossRefGoogle Scholar
  3. 3.
    Coin A et al (2000) Multiple symmetric lipomatosis: evidence for mitochondrial dysfunction. J Clin Neuromuscul Dis 1(3):124–130PubMedCrossRefGoogle Scholar
  4. 4.
    Morelli A et al (1995) RFLP analysis of human chromosome 11 region q13 in multiple symmetric lipomatosis and multiple endocrine neoplasia type 1-associated lipomas. Biochem Biophys Res Commun 207(1):363–368PubMedCrossRefGoogle Scholar
  5. 5.
    Berkovic SF et al (1991) Mitochondrial dysfunction in multiple symmetrical lipomatosis. Ann Neurol 29(5):566–569PubMedCrossRefGoogle Scholar
  6. 6.
    Conroy JP (2006) Airway management: a patient with Madelung disease. AANA J 74(4):281–284PubMedGoogle Scholar
  7. 7.
    Raguse J-D et al (2004) Benign symmetric lipomatosis (Madelung’s disease) complicated by involvement of the facial nerve. Eur J Plast Surg 27:306–308CrossRefGoogle Scholar
  8. 8.
    Poggi G et al (2006) Scrotal involvement in Madelung disease: clinical, ultrasound and MR findings. Abdom Imaging 31(4):503–505PubMedCrossRefGoogle Scholar
  9. 9.
    Soler R et al (1997) MR of laryngeal and scrotal involvement in multiple symmetrical lipomatosis. Eur Radiol 7(6):946–948PubMedCrossRefGoogle Scholar
  10. 10.
    Uppot RN et al (2007) Impact of obesity on medical imaging and image-guided intervention. AJR Am J Roentgenol 188(2):433–440PubMedCrossRefGoogle Scholar
  11. 11.
    Brodie BC (1846) Clinical lectures on surgery delivered at St. George’s Hospital. Lea and Blanchard, Philadelphia, p 201Google Scholar
  12. 12.
    Madelung OW (1888) Über den Fetthals (diffuses Lipom des Halses). Arch Klin Chir 37:106–130Google Scholar
  13. 13.
    Launois PE, Bensaude R (1898) De l’ adéno-lipomatose symétrique. Bull Mém Soc Med Hosp (Paris) 1:298Google Scholar
  14. 14.
    Enzi G et al (2002) Multiple symmetric lipomatosis: clinical aspects and outcome in a long-term longitudinal study. Int J Obes Relat Metab Disord 26(2):253–261PubMedCrossRefGoogle Scholar
  15. 15.
    Lopez-Ceres A et al (2006) Benign symmetric lipomatosis of the tongue in Madelung’s disease. J Craniomaxillofac Surg 34(8):489–493PubMedCrossRefGoogle Scholar
  16. 16.
    Argenta LC et al (1981) Benign symmetrical lipomatosis (Madelung’s disease). Head Neck Surg 3(3):240–243PubMedCrossRefGoogle Scholar
  17. 17.
    Tan O, Ergen D (2008) Madelung syndrome with pubic involvement. Dermatol Surg 34(6):811–814PubMedCrossRefGoogle Scholar
  18. 18.
    Guilemany JM, Romero E, Blanch JL (2005) An aesthetic deformity: Madelung’s disease. Acta Otolaryngol 125(3):328–330PubMedCrossRefGoogle Scholar
  19. 19.
    Leung NW et al (1987) Multiple symmetric lipomatosis (Launois-Bensaude syndrome): effect of oral salbutamol. Clin Endocrinol (Oxf) 27(5):601–606CrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • Vincenzo Penna
    • 1
    Email author
  • Niklas Iblher
    • 1
  • Jamil Al Jamali
    • 1
  • G. Bjöern Stark
    • 1
  • Gunther Felmerer
    • 1
  1. 1.Department of Plastic and Hand SurgeryUniversity Medical Centre FreiburgFreiburgGermany

Personalised recommendations