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European Journal of Plastic Surgery

, Volume 32, Issue 6, pp 315–317 | Cite as

Primary mucinous carcinoma (PMC) of the skin—a case report

  • Nau’shil Kaur Randhawa
  • Marcus T. C. Wong
Case Report
  • 54 Downloads

Abstract

Primary mucinous carcinoma of the skin is a rare malignant adnexal neoplasm. It was first described by Lennox et al. in 1952. It is uncertain whether it is of apocrine or eccrine origin (Wright and Font, Cancer 44:1757–1768, 2; Mendoza and Helwig, Arch Dermatol 103:68–78, 3). Showing morphological similarity to mucinous carcinoma of the breast, it may be difficult to distinguish it from a cutaneous metastatic deposit of mucinous adenocarcinoma from a visceral primary lesion. Hence, it deserves attention not only for its scarcity but also for the challenge in determining its precise diagnosis and hence, planning its management. We present a case of primary mucinous carcinoma of the skin.

Keywords

Primary mucinous carcinoma of the skin (PMCS) Mucin-secreting adenocarcinoma Metastasis Immuno-histochemistry 

References

  1. 1.
    Martinez SR, Young SE (2005) Primary mucinous carcinoma of the skin: a review. Int J Oncol 2:432–437Google Scholar
  2. 2.
    Wright JD, Font RL (1979) Mucinous sweat gland adenocarcinoma of eyelid. A clinicopathologic study of 21 cases with histochemical and electron microscopic observations. Cancer 4:1757–1768. doi: 10.1002/1097-0142(197911)44:5<1757::AID-CNCR2820440533>3.0.CO;2-8 CrossRefGoogle Scholar
  3. 3.
    Mendoza S, Helwig EB (1971) Mucinous (adenocystic) carcinoma of the skin. Arch Dermatol 103:68–78. doi: 10.1001/archderm.103.1.68 CrossRefPubMedGoogle Scholar
  4. 4.
    Pilgrim JP, Wolfish PS, Kloss SG et al (1985) Primary mucinouscarcinoma of the skin with metastases to the lymph nodes. Am J Dermatopathol 7:461–469. doi: 10.1097/00000372-198510000-00011 PubMedGoogle Scholar
  5. 5.
    Rao KV, Tikku I, Kapur BML et al (1978) Invasive primary mucinous carcinoma of the skin. Int Surg 63:168–170PubMedGoogle Scholar
  6. 6.
    Abe S, Matsumoto Y, Fujita T (1997) Primary mucinous carcinoma of the skin. Plast Reconstr Surg 99:1160–1161. doi: 10.1097/00006534-199704000-00040 CrossRefPubMedGoogle Scholar
  7. 7.
    Weber PJ, Hevia O, Gretzula JC, Rabinovitz HC (1988) Primary mucinous carcinoma. J Dermatol Surg Oncol 14:170–172PubMedGoogle Scholar
  8. 8.
    Smoller BR, Narurkar V (1992) Mucoepidermoid carcinoma metastatic to the skin: an histologic mimic of a primary sweat gland carcinoma. J Dermatol Surg Oncol 18:365–368PubMedGoogle Scholar
  9. 9.
    Balin AK, Fine RM, Golitz LE (1988) Mucinous carcinoma. J Dermatol Surg Oncol 14:521–524PubMedGoogle Scholar
  10. 10.
    Karimipour DJ, Johnson TM, Kang S, Wang TS, Lowe L (1996) Mucinous carcinoma of the skin. J Am Acad Dermatol 34:323–326. doi: 10.1016/S0190-9622(96)80151-4 CrossRefGoogle Scholar
  11. 11.
    Santa-Cruz DJ, Meyers JH, Gnepp DR et al (1978) Primary mucinous carcinoma of the skin. Br J Dermatol 98:645–653. doi: 10.1111/j.1365-2133.1978.tb03583.x CrossRefPubMedGoogle Scholar
  12. 12.
    Anderson PJ, Dobson CM, Berry RB (2004) Mucinous adenocarcinoma of the face. A case report. Int J Oral Maxillofac Surg 33:610–612. doi: 10.1016/j.ijom.2003.08.004 CrossRefPubMedGoogle Scholar
  13. 13.
    Breiting L, Christensen L, Dahlstrom K, Breiting V, Winther JF (2008) Primary mucinous carcinoma of the skin: a population-based study. Int J Dermatol 47:242–245. doi: 10.1111/j.1365-4632.2008.03558.x CrossRefPubMedGoogle Scholar
  14. 14.
    Kazakov DV, Suster S, LeBoit PE et al (2005) Mucinous carcinoma of the skin, primary and secondary: a clinicopathologic study of 63 cases with emphasis on the morphologic spectrum of primary cutaneous forms: homologies with mucinous lesions in the breast. Am J Surg Pathol 29:764–782. doi: 10.1097/01.pas.0000159104.02985.6b CrossRefPubMedGoogle Scholar
  15. 15.
    Ortiz KJ, Gaughan MD, Bang R et al (2002) A case of primary mucinous carcinoma of the scalp treated with Mohs surgery. Dermatol Surg 28:751–754. doi: 10.1046/j.1524-4725.2002.02007.x CrossRefPubMedGoogle Scholar
  16. 16.
    Hanby AM, Mckee P, Jeffery M et al (1998) Primary mucinous carcinoma of the skin expresses TFF1, TFF3, estrogen receptor, and progesterone receptors. Am J Surg Pathol 22:1125–1131. doi: 10.1097/00000478-199809000-00012 CrossRefPubMedGoogle Scholar
  17. 17.
    Snow SN, Reizner GT (1992) Muccinous eccrine carcinoma of the eyelid. Cancer 70:2099–2104. doi: 10.1002/1097-0142(19921015)70:8<2099::AID-CNCR2820700815>3.0.CO;2-C CrossRefPubMedGoogle Scholar
  18. 18.
    Carson HJ, Gattuso P, Raslan WF et al (1995) Mucinous carcinoma of the eyelid. An immunohistochemical study. Am J Dermatopathol 17:494–498PubMedCrossRefGoogle Scholar
  19. 19.
    Osaki T, Hirota J, Ohno A, Tatemoto Y (1990) Mucinous adenocarcinoma of the submandibular gland. Cancer 66:1796–1801. doi: 10.1002/1097-0142(19901015)66:8<1796::AID-CNCR2820660826>3.0.CO;2-K CrossRefPubMedGoogle Scholar
  20. 20.
    Krogdahl AS, Schou C (1997) Mucinous adenocarcinoma of the sublingual gland. J Oral Pathol Med 26:198–200. doi: 10.1111/j.1600-0714.1997.tb00458.x CrossRefPubMedGoogle Scholar
  21. 21.
    Gamez-Araujo JJ, Ayala AG, Guillamondegui O (1975) Mucinous adenocarcinomas of nose and paranasal sinuses. Cancer 36:1100–1105. doi: 10.1002/1097-0142(197509)36:3<1100::AID-CNCR2820360339>3.0.CO;2-R CrossRefPubMedGoogle Scholar
  22. 22.
    Notani K, Iizuka T, Yamazaki Y, Henmi T, Sugiura C, Kohgo T, Fukuda H (2002) Mucinous adenocarcinoma of probable minor salivary gland origin. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 94:738–740. doi: 10.1067/moe.2002.126698 CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Nau’shil Kaur Randhawa
    • 1
  • Marcus T. C. Wong
    • 1
  1. 1.Section of Plastic, Reconstructive and Aesthetic Surgery, Department of General SurgeryTan Tock Seng HospitalSingaporeSingapore

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