Sentinel lymph node mapping for patients with Merkel cell carcinoma—experience of 5 years

  • J. Liebau
  • A. Arens
  • V. Schwipper
  • A. Schulz
Original Article


Merkel cell carcinoma (MCC) is a rare, highly malignant carcinoma of the neuroendocrinological system (Bayrou et al., J Am Acad Dermatol 24:198–207, 1992). It is a fast-growing, aggressive tumor with a high rate of local recurrence and early metastases. A radical surgical procedure is the therapy of choice. In case of lymph node metastases, regional lymphadenectomy is mandatory. Sentinel lymph node (SLN) mapping is a standard diagnostic technique to detect micrometastases in certain patients with malignant melanoma and breast cancer. The question is, can the SLN technique provide information as a prognostic factor and can the prognosis of the MCC be improved by detecting micrometastases in SLN at an early stage?


Merkel cell carcinoma Sentinel lymph node mapping 


  1. 1.
    Allen PJ, Zhang ZF, Coit DG (1999) Surgical management of Merkel cell carcinoma. Ann Surg 229:97–105PubMedCrossRefGoogle Scholar
  2. 2.
    Bayrou O, Avril MF, Charpentier P et al (1992) Primary neuroendocrine carcinoma of the skin: clinicopathological study of 18 cases. J Am Acad Dermatol 24:198–207CrossRefGoogle Scholar
  3. 3.
    Bickle K, Glass LF, Messina JL, Fenske NA, Siegrist K (2004) Merkel cell carcinoma: a clinical, histopathologic, and immunohistochemical review. Semin Cutan Med Surg 23(1):46–53PubMedCrossRefGoogle Scholar
  4. 4.
    Bielamowicz S, Smith D, Abemayor E (1994) Merkel cell carcinoma: an aggressive skin neoplasm. Laryngoscope 104:528–532PubMedCrossRefGoogle Scholar
  5. 5.
    Blom A, Kolb F, Lumbroso J, Duvillard P, Mamelle G, Ricard M, Spatz A, Petrow P, Margulis A, Avril MF (2003) Significance of sentinel lymph node biopsy in Merkel cell carcinoma. Ann Dermatol Venereol 130(4):17–22Google Scholar
  6. 6.
    Brady MS (2004) Currant management of patients with Merkel cell carcinoma. Dermatol Surg 30:321–325PubMedCrossRefGoogle Scholar
  7. 7.
    Hill AD, Brady MS, Coit DG (1999) Intraoperative lymphatic mapping and sentinel lymph node biopsy for Merkel cell carcinoma. Br J Surg 86:518–521PubMedCrossRefGoogle Scholar
  8. 8.
    Meeuwissen JA, Bourne RG, Kearsley JH (1995) The importance of postoperative radiation therapy in the treatment of Merkel cell carcinoma. Int J Radiat Oncol Biol Phys 31:325–331Google Scholar
  9. 9.
    Rodrigues LK, Leong SP, Kashani-Sabet M, Wong JH (2001) Early experience with sentinel lymph node mapping for Merkel cell carcinoma. J Am Acad Dermatol 45(2):303–308PubMedCrossRefGoogle Scholar
  10. 10.
    Smith DE, Bielamowicz S, Kagan AR, Anderson PJ, Peddada AV (1995) Cutaneous neuroendocrine (Merkel cell) carcinoma: a report of 35 cases. Am J Clin Oncol 18:199–203PubMedGoogle Scholar
  11. 11.
    Su LD, Fullen DR, Lowe L, Uherova P, Schnitzer B, Valdez R (2002) CD117 (KIT receptor) expression in Merkel cell carcinoma. Am J Dermatopathol 24(4):289–293PubMedCrossRefGoogle Scholar
  12. 12.
    Toker C (1972) Trabecular carcinoma of the skin. Arch Dermatol 105:107–110PubMedCrossRefGoogle Scholar
  13. 13.
    Yiengpruksawan A, Croit DG, Thaler HT, Urmacher C, Knapper WK (1991) Merkel cell carcinoma: prognosis and management. Arch Surg 126:1514–1519PubMedGoogle Scholar
  14. 14.
    McAfee WJ, Morris CG, Mendenhall CM, Werning JW, Mendenhall NP, Mendenhall WM (2005) Merkel cell carcinoma: treatment and outcomes. Cancer 104(8):1761–1764PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  1. 1.Department of Plastic SurgeryFachklinik Hornheide at the Westfalian Wilhelms UniversityMünsterGermany
  2. 2.Klinik für Plastische Chirurgie, Kaiserswerther DiakonieFlorence-Nightingale-KrankenhausDüsseldorfGermany

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