Neuroradiology

, Volume 40, Issue 3, pp 150–153 | Cite as

Radiological assessment of necrosis in glioblastoma: variability and prognostic value

  • A. Pierallini
  • M. Bonamini
  • P. Pantano
  • F. Palmeggiani
  • M. Raguso
  • M. F. Osti
  • G. Anaveri
  • L. Bozzao
DIAGNOSTIC NEURORADIOLOGY

Abstract

In a previous study, we found that the extent of necrosis was the only radiological feature which correlated significantly with survival in patients with glioblastoma. The aim of this paper was to evaluate the variability and prognostic value of the extent of the necrotic area as seen on contrast-enhanced MRI and CT in a larger series. We studied 72 patients who underwent surgical removal of supratentorial glioblastomas and had CT and/or MRI with contrast medium before surgery; 38, all undergoing the same treatment (surgery plus radiotherapy), were followed clinically. Necrosis within the tumour varied greatly, ranging from none (only 1 case) to involvement of 76 % of the tumour. Survival data in the subgroup suggested that only patients with a small area of necrosis (less than 35 % of the tumour) had a significantly longer survival time. When necrosis involved more than 35 % of the mass, patients had a shorter survival time, without any further correlation with the extent of necrosis.

Key words Glioblastoma necrosis Magnetic resonance imaging Computed tomography 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1998

Authors and Affiliations

  • A. Pierallini
    • 1
  • M. Bonamini
    • 1
  • P. Pantano
    • 1
  • F. Palmeggiani
    • 2
  • M. Raguso
    • 3
  • M. F. Osti
    • 2
  • G. Anaveri
    • 2
  • L. Bozzao
    • 1
  1. 1.Neuroradiology Section, Department of Neurological Sciences, University of Rome “La Sapienza”, Viale dell'Università 30, I-00185 Rome, Italy Tel.: + 39-6-49 91 43 08 Fax: + 39-6-49 91 49 03IT
  2. 2.Department of Radiation Oncology, University of Rome “La Sapienza”, Rome, ItalyIT
  3. 3.IRCCS Neuromed, Pozzili (IS)

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