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Neuroradiology

, Volume 39, Issue 7, pp 523–528 | Cite as

Magnetization transfer in the investigation of patients with tuberous sclerosis

  • N. Girard
  • R. A. Zimmerman
  • R. E. Schnur
  • J. Haselgrove
  • K. Christensen
PEDIATRIC NEURORADIOLOGY

Abstract

We examined 21 patients aged 5 months to 19 years, on a 1.5 T magnet. T1-weighted spin-echo images, proton density and T2-weighted images with spin-echo and turbo spin-echo sequences, and contrast-enhanced magnetization transfer (MT) T1-weighted images were obtained in all cases. MT T1-weighted images were performed before injection in 9 patients. Subependymal nodules were found in 14, and cortical and subcortical tubers in 20 of the 21 patients. MT T1-weighted images showed tubers and subependymal nodules as higher signal than normal gray matter and revealed more tubers than conventional sequences in 11 cases. High signal intensity lesions of the white matter were found in 19 patients but were seen only on MT images in 9 cases. When MT images both before and after injection were available, tubers and white matter lesions were more easily recognised on unenhanced MT images because of their higher contrast.

Key words Magnetization transfer Phakomatoses Brain magnetic resonance imaging Sclerosis tuberous 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1997

Authors and Affiliations

  • N. Girard
    • 1
  • R. A. Zimmerman
    • 2
  • R. E. Schnur
    • 3
  • J. Haselgrove
    • 2
  • K. Christensen
    • 3
  1. 1.Department of Neuroradiology, Hopital Nord, F-13385 Marseille Cedex 5, France FR
  2. 2.Department of Radiology, The Children's Hospital of Philadelphia, 34th St. & Civic Center Blvd., Philadelphia, PA 19104, USAUS
  3. 3.Department of Pediatrics and Genetics The Children's Hospital of Philadelphia Philadelphia, PA 19104, USAUS

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