Neuroradiology

, Volume 43, Issue 2, pp 169–177 | Cite as

Proton magnetic spectroscopic imaging of the child's brain: the response of tumors to treatment

  • A. A. Tzika
  • D. Zurakowski
  • T. Young Poussaint
  • L. Goumnerova
  • L. G. Astrakas
  • P. D. Barnes
  • D. C. Anthony
  • A. L. Billett
  • N. J. Tarbell
  • R. M. Scott
  • P. McL. Black
PAEDIATRIC NEURORADIOLOGY

Abstract

Our aim was to determine and/or predict response to treatment of brain tumors in children using proton magnetic resonance spectroscopic imaging (MRSI). We studied 24 patients aged 10 months to 24 years, using MRI and point-resolved spectroscopy (PRESS; TR 2000 TE 65 ms) with volume preselection and phase-encoding in two dimensions on a 1.5 T imager. Multiple logistic regression was used to establish independent predictors of active tumor growth. Biologically vital cell metabolites, such as N-acetyl aspartate and choline-containing compounds (Cho), were significantly different between tumor and control tissues (P < 0.001). The eight brain tumors which responded to radiation or chemotherapy, exhibited lower Cho (P = 0.05), higher total creatine (tCr) (P = 0.02) and lower lactate and lipid (L) (P = 0.04) than16 tumors which were not treated (except by surgery) or did not respond to treatment. The only significant independent predictor of active tumor growth was tCr (P < 0.01). We suggest that tCr is useful in assessing response of brain tumors to treatment.

Key words Brain tumors Children Magnetic resonance spectroscopy 

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Copyright information

© Springer-Verlag Berlin Heidelberg 2001

Authors and Affiliations

  • A. A. Tzika
    • 1
  • D. Zurakowski
    • 2
  • T. Young Poussaint
    • 1
  • L. Goumnerova
    • 3
  • L. G. Astrakas
    • 1
  • P. D. Barnes
    • 1
  • D. C. Anthony
    • 4
  • A. L. Billett
    • 5
  • N. J. Tarbell
    • 5
  • R. M. Scott
    • 3
  • P. McL. Black
    • 3
  1. 1.Department of Radiology, Children's Hospital and Harvard Medical School, Boston, MA, USAUS
  2. 2.Department of Biostatistics, Children's Hospital and Harvard Medical School, Boston, MA, USAUS
  3. 3.Department of Neurosurgery, Children's Hospital and Harvard Medical School, Boston, MA, USAUS
  4. 4.Department of Pathology, Children's Hospital and Harvard Medical School, Boston, MA, USAUS
  5. 5.Department of Radiation Oncology, Children's Hospital and Harvard Medical School, Boston, MA, USAUS

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