Neuroimaging characteristics and long-term prognosis of myxoma-related intracranial diseases

  • Shuo Zhang
  • Qian Zhang
  • Hai Yu
  • Longqi Liu
  • Rujing Sun
  • Xiaowen Song
  • Xianzeng Tong
  • Yueshan Piao
  • Xin Chen
  • Jun Wu
  • Yong Cao
  • Shuo Wang
  • Jizong ZhaoEmail author
Diagnostic Neuroradiology



Myxoma-related intracranial diseases were rarely documented in history. The main purpose of our study is to provide a more comprehensive and detailed understanding of the pathogenesis, imaging features, surgical procedures and pathology of such patients through long-term follow-up.


From March 2012 to July 2018, baseline information that included neuroimaging and neuropathology data from 12 cardiac myxoma patients with neurological symptoms were retrospectively analysed, and the treatment options were discussed. Nine patients underwent long-term postoperative follow-up.


Twelve cardiac myxoma patients with neurological symptoms were identified, and among them, 10 patients were postoperative patients who had undergone excision of cardiac myxoma, 5 patients had received craniotomy, and the others had received conservative treatment. Positive neuroimaging findings were found in all patients, including cerebral infarction (12/12, 100%), multiple intracranial aneurysms (8/12, 67%), and extravascular metastasis (6/12, 50%). After a long-term average follow-up of 27 months, an increased number of metastatic lesions or an enlargement of the intracranial aneurysms was found in 4 patients.


Neuroimaging findings of myxoma-related intracranial lesions were diversed and usually presented as multiple cerebral infarction, aneurysm formation, focal intracranial haemorrhage and space-occupying lesions. Progress is over a long period of time after primary tumour resection. It is necessary for patients to be regularly examined within 2 years after cardiac myxoma resection using MRI+CTA/MRA/DSA in order to be ruled out. Stable and effective chemotherapy drugs are urgently needed.


Cardiocerebral comorbidity Myxoma Intracranial metastases Cerebral infarction Multiple intracranial aneurysms 


Funding information

This study was funded by the “13th Five-Year Plan” National Science and Technology Supporting Plan (2015BAI12B04) and the Beijing Municipal Administration of Hospitals’ Mission Plan (SML20150501).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

For this type of study, formal consent is not required.

Informed consent

Informed consent was obtained from all individual participants included in the study.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  • Shuo Zhang
    • 1
    • 2
  • Qian Zhang
    • 1
    • 2
  • Hai Yu
    • 3
  • Longqi Liu
    • 4
  • Rujing Sun
    • 5
  • Xiaowen Song
    • 1
    • 2
  • Xianzeng Tong
    • 6
  • Yueshan Piao
    • 7
  • Xin Chen
    • 1
    • 2
  • Jun Wu
    • 1
    • 2
  • Yong Cao
    • 1
    • 2
  • Shuo Wang
    • 1
    • 2
  • Jizong Zhao
    • 1
    • 2
    Email author
  1. 1.Department of Neurosurgery, Beijing Tiantan HospitalCapital Medical UniversityBeijingPeople’s Republic of China
  2. 2.China National Clinical Research Center for Neurological DiseasesBeijingPeople’s Republic of China
  3. 3.Department of Cardiac Surgery, Beijing Anzhen HospitalCapital Medical UniversityBeijingChina
  4. 4.Departments of NeurosurgeryJishuitan Hospital, Peking UniversityBeijingPeople’s Republic of China
  5. 5.Department of Neuroimaging, Beijing Tiantan HospitalCapital Medical UniversityBeijingPeople’s Republic of China
  6. 6.Departments of Neurosurgery, Xuanwu HospitalCapital Medical UniversityBeijingChina
  7. 7.Departments of Pathology, Xuanwu HospitalCapital Medical UniversityBeijingChina

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