Predictive value of the combination of lesion location and volume of ischemic infarction with rehabilitation outcomes

  • Chen LinEmail author
  • Neil Chatterjee
  • Jungwha Lee
  • Richard Harvey
  • Shyam Prabhakaran
Diagnostic Neuroradiology



In acute ischemic stroke, infarct location and volume have, separately, been used to determine long-term outcomes after stroke. Little information exists on the combination of these imaging characteristics on rehabilitation outcomes. We evaluated the association between infarct lesion location volume with the Functional Independence Measure (FIM) measure during inpatient rehabilitation facility (IRF) in ischemic stroke patients.


Between 2012 and 2014, we prospectively enrolled consecutive acute ischemic stroke patients admitted from a Comprehensive Stroke Center and followed to an IRF in Chicago, Illinois. We adjudicated infarct volumes in specific lesion locations using a validated brain atlas. Volumes were calculated using an automated pipeline. FIM measure was extracted from IRF charts. We analyzed the association between acute infarct characteristics and functional measures using adjusted Spearman’s correlation.


Among 162 stroke patients (mean age 67.6 years, 48.1% male, 58.6% Caucasian), the median FIM at IRF was 52 (IQR 36–62). In an adjusted analysis, infarct volumes in the left basal ganglia (rs = − 0.45, p = 0.02) and left frontal lobe (rs = − 0.38, p = 0.04) were negatively correlated with FIM scores.


There is an association between specific infarct lesion location volume and subsequent FIM scores assessed at IRF. Our findings suggest that imaging during index stroke hospitalization could be used to predict outcomes assessed during IRF.


Infarct size Infarct location Patient outcomes Cerebrovascular imaging Volumetry Stroke rehabilitation 



This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

Compliance with ethical standards

Conflict of Interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

Supplementary material

234_2019_2234_MOESM1_ESM.docx (27 kb)
ESM 1 (DOCX 26 kb)


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.University of Alabama BirminghamBirminghamUSA
  2. 2.Northwestern UniversityChicagoUSA

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