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Neuroradiology

, Volume 61, Issue 1, pp 13–15 | Cite as

“Pseudo” T1-weighted appearance of the brain on FLAIR: unmasking the extent of gray matter involvement on susceptibility-weighted imaging in chronic toluene abuse

  • Charlie Chia-Tsong HsuEmail author
  • E. Mark Haacke
  • Chinthaka Heyn
  • Kosuke Kato
  • Trevor William Watkins
  • Timo Krings
Letter to the Editor

Dear Editor-in-Chief,

Toluene is a readily accessible neurotoxic organic solvent present in paints, inks, glues, and thinners. Chronic toluene abuse through inhalation causes progressive debilitating neurologic complications including cognitive impairment, cerebellar, and extrapyramidal symptoms [1, 2]. White matter involvement is perhaps the most well-recognized radiologic feature of chronic toluene abuse. White matter lesions are localized to the periventricular region in early stages and become more confluent with subsequent involvement of the subcortical U-fibers [3, 4]. The extent of white matter involvement on MRI correlates with the severity of cognitive impairment [1, 2]. Less emphasized radiologic findings of toluene abuse are the involvement of cortical and central gray matter (basal ganglia and thalami) which manifests as low-signal intensity on the T2-weighted spin echo or T2*-weighted gradient echo (GRE) sequences [3, 4, 5, 6]. A causal relationship between the white and...

Notes

Compliance with ethical standards

Funding

No funding was received for this study.

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in the studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Medical ImagingGold Coast University HospitalSouthportAustralia
  2. 2.Departments of Radiology and Biomedical EngineeringWayne State UniversityDetroitUSA
  3. 3.Department of Medical ImagingSunnybrook Health Sciences Centre and University of TorontoTorontoCanada
  4. 4.Physical SciencesSunnybrook Research InstituteTorontoCanada
  5. 5.Department of Medical ImagingPrincess Alexandra HospitalBrisbaneAustralia
  6. 6.Joint Department of Medical ImagingToronto Western Hospital and University Health NetworkTorontoCanada

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