Automated ASPECT rating: comparison between the Frontier ASPECT Score software and the Brainomix software
- 243 Downloads
Computer-aided diagnosis (CAD) appears promising in early ischemic change detection computed tomography (CT). This study aimed to compare the performance of two new CAD systems (Frontier ASPECTS Prototype and Brainomix) with two experienced readers in selected patients with suspected acute ischemic stroke.
Retrospectively, non-contrast brain CTs of 150 patients suspected for acute middle cerebral artery ischemia were analyzed with respect to ASPECTS first separately, than in consensus by two senior radiologists, and by use of Frontier and Brainomix. Besides the fully automatic Frontier and Brainomix readings (Frontier_1, Brainomix_1), readings adjusted for the affected brain side (known by CT angiography or clinical presentation, Frontier_2, Brainomix_2) were assessed. Statistical analysis was performed by intraclass correlation and Bland-Altman statistics.
The score-based ASPECTS readings of Brainomix_1, Brainomix_2, both radiologists, and the expert consensus reading correlated highly (r = 0.714 to 0.841; always p < 0.001), whereas Frontier_1 and Frontier_2 correlated only lowly or moderately with both radiologists, the expert consensus reading, and Brainomix (r = 0.471 to 0.680; always p < 0.001). Bland-Altman analysis revealed lower mean ASPECT difference and standard deviation of difference for Brainomix_2 (mean difference = −0.2; SD = 1.15) compared to Frontier_2 (mean difference = 1.2; SD = 1.76). Correlation of region-based ASPECTS reading with the expert consensus reading was moderate for Brainomix_2 (r = 0.534), but only low for Frontier_2 (r = 0283; always p < 0.001).
We found high agreement in ASPECTS rating between both radiologists, expert consensus reading, and Brainomix, but only low to moderate agreement to Frontier.
KeywordsArtificial intelligence Computer-aided diagnosis Early ischemic change detection Brain computed tomography ASPECTS
Compliance with ethical standards
No funding was received for this study.
Conflict of Interest
The authors declare that they have no conflict of interest.
All procedures performed in the studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. For this type of study formal consent is not required.
Informed consent was obtained from all individual participants included in the study.
- 8.von Kummer R, Meyding-Lamade U, Forsting M et al (1994) Sensitivity and prognostic value of early CT in occlusion of the middle cerebral artery trunk. AJNR Am J Neuroradiol 15:9–15 discussion 16-18Google Scholar
- 10.Frontier server user manuals ASPECT Score Prototype V1_2_0. Siemens Healthcare GmbH, ErlangenGoogle Scholar
- 12.Nagel S, Sinha D, Day D, Reith W, Chapot R, Papanagiotou P, Warburton EA, Guyler P, Tysoe S, Fassbender K, Walter S, Essig M, Heidenrich J, Konstas AA, Harrison M, Papadakis M, Greveson E, Joly O, Gerry S, Maguire H, Roffe C, Hampton-Till J, Buchan AM, Grunwald IQ (2017) e-ASPECTS software is non-inferior to neuroradiologists in applying the ASPECT score to computed tomography scans of acute ischemic stroke patients. Int J Stroke 12:615–622CrossRefGoogle Scholar