, Volume 60, Issue 9, pp 903–912 | Cite as

Comparison of field-of-view optimized and constrained undistorted single-shot diffusion-weighted imaging and conventional diffusion-weighted imaging of optic nerve and chiasma at 3T

  • Yuan Tian
  • Junqing Wang
  • Mingge Li
  • Xin Lou
  • Jing Tang
  • Quangang Xu
  • Yingkui Zhang
  • Shihui Wei
  • Lin MaEmail author
Diagnostic Neuroradiology



Single-shot echo-planar imaging is the conventional diffusion-weighted imaging (C-DWI) sequence for evaluating orbital disease. However, its utility is restricted in small organs like the chiasma and optic nerve. This study was conducted to investigate the utility of field-of-view optimized and constrained undistorted single-shot diffusion-weighted imaging (FOCUS-DWI) for evaluating the chiasma and optic nerve in acute optic neuritis, making comparisons with C-DWI.


FOCUS-DWI and C-DWI were performed on 36 acute optic neuritis patients and 16 normal controls. Two readers assessed image quality using 5-point Likert scales. Differences in the visual assessments and apparent diffusion coefficient (ADC) values between C-DWI and FOCUS-DWI were evaluated. Inter-observer agreement in the qualitative data was assessed using Cohen’s kappa coefficients. Inter- and intra-observer agreements in the ADC values were evaluated using intraclass correlation coefficients.


FOCUS-DWI was superior to C-DWI in all aspects of the image evaluations. The Cohen’s kappa coefficients for FOCUS-DWI were almost perfect (0.81–1) or substantial (0.61–0.80) for all the image quality categories. In the FOCUS-DWI images, the structural conspicuity of the chiasma and canalicular and cisternal segments was significantly superior on coronal views than on axial views (P < 0.0001). ROC analysis showed that in optic neuritis patients, the diagnostic value of ADC measurements on FOCUS-DWI was higher than ADC values measured on C-DWI.


The FOCUS-DWI technique can provide substantial improvements over C-DWI for imaging different aspects of the optic nerve and chiasma. The coronal scan direction is more suitable than the axial scan direction for FOCUS-DWI.


Optic nerves Acute optic neuritis Diffusion-weighted imaging Magnetic resonance imaging 



We thank Karl Embleton, PhD, Liwen Bianji, Edanz Group China (, for language editing.

Compliance with ethical standards


No funding was received for this study.

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in the studies involving human participants were in accordance with the ethical standards of Chinese PLA General Hospital and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

Supplementary material

234_2018_2058_MOESM1_ESM.docx (15 kb)
Supplementary Table 1 (DOCX 14 kb)


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Yuan Tian
    • 1
    • 2
  • Junqing Wang
    • 3
  • Mingge Li
    • 1
  • Xin Lou
    • 1
  • Jing Tang
    • 1
  • Quangang Xu
    • 3
  • Yingkui Zhang
    • 4
  • Shihui Wei
    • 3
  • Lin Ma
    • 1
    Email author
  1. 1.Department of RadiologyChinese PLA General HospitalBeijingChina
  2. 2.Department of Radiology309th Hospital of Chinese People’s Liberation ArmyBeijingChina
  3. 3.Department of OphthalmologyChinese PLA General HospitalBeijingChina
  4. 4.HCS Application-MR, Economic & Technology Development AreaGE HealthcareBeijingChina

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