, Volume 60, Issue 6, pp 599–608 | Cite as

Comparative study of pulsed-continuous arterial spin labeling and dynamic susceptibility contrast imaging by histogram analysis in evaluation of glial tumors

  • Atsuko Arisawa
  • Yoshiyuki WatanabeEmail author
  • Hisashi Tanaka
  • Hiroto Takahashi
  • Chisato Matsuo
  • Takuya Fujiwara
  • Masahiro Fujiwara
  • Yasunori Fujimoto
  • Noriyuki Tomiyama
Diagnostic Neuroradiology



Arterial spin labeling (ASL) is a non-invasive perfusion technique that may be an alternative to dynamic susceptibility contrast magnetic resonance imaging (DSC-MRI) for assessment of brain tumors. To our knowledge, there have been no reports on histogram analysis of ASL. The purpose of this study was to determine whether ASL is comparable with DSC-MRI in terms of differentiating high-grade and low-grade gliomas by evaluating the histogram analysis of cerebral blood flow (CBF) in the entire tumor.


Thirty-four patients with pathologically proven glioma underwent ASL and DSC-MRI. High-signal areas on contrast-enhanced T1-weighted images or high-intensity areas on fluid-attenuated inversion recovery images were designated as the volumes of interest (VOIs). ASL-CBF, DSC-CBF, and DSC-cerebral blood volume maps were constructed and co-registered to the VOI. Perfusion histogram analyses of the whole VOI and statistical analyses were performed to compare the ASL and DSC images.


There was no significant difference in the mean values for any of the histogram metrics in both of the low-grade gliomas (n = 15) and the high-grade gliomas (n = 19). Strong correlations were seen in the 75th percentile, mean, median, and standard deviation values between the ASL and DSC images. The area under the curve values tended to be greater for the DSC images than for the ASL images.


DSC-MRI is superior to ASL for distinguishing high-grade from low-grade glioma. ASL could be an alternative evaluation method when DSC-MRI cannot be used, e.g., in patients with renal failure, those in whom repeated examination is required, and in children.


Dynamic susceptibility contrast imaging Glial tumors Histogram analysis Pulsed-continuous arterial spin labeling 


Compliance with ethical standards


No funding was received for this study.

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in the studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

Informed consent

For this type of study formal consent is not required.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Atsuko Arisawa
    • 1
  • Yoshiyuki Watanabe
    • 1
    Email author
  • Hisashi Tanaka
    • 1
  • Hiroto Takahashi
    • 1
  • Chisato Matsuo
    • 1
  • Takuya Fujiwara
    • 1
  • Masahiro Fujiwara
    • 1
  • Yasunori Fujimoto
    • 2
  • Noriyuki Tomiyama
    • 1
  1. 1.Department of Diagnostic and Interventional RadiologyOsaka University Graduate School of MedicineOsakaJapan
  2. 2.Department of NeurosurgeryOsaka University Graduate School of MedicineOsakaJapan

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