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Neuroradiology

, Volume 60, Issue 3, pp 255–265 | Cite as

Transit time corrected arterial spin labeling technique aids to overcome delayed transit time effect

  • Tae Jin Yun
  • Chul-Ho SohnEmail author
  • Roh-Eul Yoo
  • Kyung Mi Kang
  • Seung Hong Choi
  • Ji-hoon Kim
  • Sun-Won Park
  • Moonjung Hwang
  • R. Marc Lebel
Diagnostic Neuroradiology

Abstract

Purpose

This study aimed to evaluate the usefulness of transit time corrected cerebral blood flow (CBF) maps based on multi-phase arterial spin labeling MR perfusion imaging (ASL-MRP).

Methods

The Institutional Review Board of our hospital approved this retrospective study. Written informed consent was waived. Conventional and multi-phase ASL-MRPs and dynamic susceptibility contrast MR perfusion imaging (DSC-MRP) were acquired for 108 consecutive patients. Vascular territory-based volumes of interest were applied to CBF and time to peak (TTP) maps obtained from DSC-MRP and CBF maps obtained from conventional and multi-phase ASL-MRPs. The concordances between normalized CBF (nCBF) from DSC-MRP and nCBF from conventional and transition time corrected CBF maps from multi-phase ASL-MRP were evaluated using Bland-Altman analysis. In addition, the dependence of difference between nCBF (ΔnCBF) values obtained from DSC-MRP and conventional ASL-MRP (or multi-phase ASL-MRP) on TTP obtained from DSC-MRP was also analyzed using regression analysis.

Results

The values of nCBFs from conventional and multi-phase ASL-MRPs had lower values than nCBF based on DSC-MRP (mean differences, 0.08 and 0.07, respectively). The values of ΔnCBF were dependent on TTP values from conventional ASL-MRP technique (F = 5.5679, P = 0.0384). No dependency of ΔnCBF on TTP values from multi-phase ASL-MRP technique was revealed (F = 0.1433, P > 0.05).

Conclusion

The use of transit time corrected CBF maps based on multi-phase ASL-MRP technique can overcome the effect of delayed transit time on perfusion maps based on conventional ASL-MRP.

Keywords

Cerebral blood flow Cerebral hemodynamics Arterial spin labeling Perfusion-weighted MRI 

Notes

Acknowledgements

The enhanced ASL-PWI sequence is a work-in-progress prototype (not commercially available) provided by GE.

Compliance with ethical standards

Funding

No funding was received for this study.

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in the studies involving human participants were in accordance with the ethical standards of the Seoul National University Hospital Institutional Review Board and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. For this type of study formal consent is not required.

Informed consent

For this type of retrospective study formal consent is not required.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2017

Authors and Affiliations

  • Tae Jin Yun
    • 1
    • 2
  • Chul-Ho Sohn
    • 1
    • 2
    Email author
  • Roh-Eul Yoo
    • 1
    • 2
  • Kyung Mi Kang
    • 1
    • 2
  • Seung Hong Choi
    • 1
    • 2
  • Ji-hoon Kim
    • 1
    • 2
  • Sun-Won Park
    • 1
    • 3
  • Moonjung Hwang
    • 4
  • R. Marc Lebel
    • 5
  1. 1.Institute of Radiation MedicineSeoul National University Medical Research CenterSeoulRepublic of Korea
  2. 2.Department of RadiologySeoul National University HospitalSeoulRepublic of Korea
  3. 3.Department of RadiologySeoul National University Boramae Medical CenterSeoulRepublic of Korea
  4. 4.GE Healthcare KoreaSeoulRepublic of Korea
  5. 5.GE Healthcare CanadaCalgaryCanada

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