, Volume 59, Issue 11, pp 1111–1119 | Cite as

Imaging findings of primary immunoglobulin G4-related cervical lymphadenopathy

  • Masaya Kawaguchi
  • Hiroki KatoEmail author
  • Yusuke Kito
  • Keisuke Mizuta
  • Mitsuhiro Aoki
  • Keizo Kato
  • Satoshi Goshima
  • Masayuki Matsuo
Head-Neck-ENT Radiology



The purpose of the present study was to assess imaging findings of primary immunoglobulin G4 (IgG4)-related cervical lymphadenopathy.


Five consecutive patients with clinically, serologically, and histopathologically confirmed primary IgG4-related cervical lymphadenopathy without any other organ involvement were included. All patients underwent contrast-enhanced computed tomography (CT), and four underwent 18F-fluorodeoxyglucose (FDG)-positron emission tomography (PET)/CT. We retrospectively reviewed the images and assessed the number, size, location, central necrosis, perinodal infiltration, penetrating vessels, and maximum standardized uptake values (SUVmax) of the enlarged cervical nodes.


Thirteen enlarged cervical nodes measuring larger than 10 mm in minimum diameter were identified. The maximum and minimum diameter of enlarged nodes ranged from 1.2 to 3.2 cm (median, 1.8 cm) and from 1.0 to 1.9 cm (median, 1.2 cm), respectively. Lymphadenopathy was unilateral in all patients, and eight enlarged nodes were located at level IB (62%), one at level II (8%), three at level IV (23%), and one at level V (8%). Central necrosis was not seen in any nodes. Perinodal infiltration was seen in only one node (8%), and penetrating vessels were seen in seven nodes (54%). The median SUVmax of nine nodes was 4.45 (range, 2.08–12.44).


Eight enlarged nodes (62%) were located in the submandibular region. Central necrosis was not observed in any nodes and perinodal infiltration was observed in one node (8%).


IgG4-related disease IgG4-related lymphadenopathy Submandibular CT FDG-PET/CT 


Compliance with ethical standards


No funding was received for this study.

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. For this type of study formal consent is not required.

Informed consent

For this type of retrospective study formal consent is not required.


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Copyright information

© Springer-Verlag GmbH Germany 2017

Authors and Affiliations

  1. 1.Department of RadiologyGifu University School of MedicineGifuJapan
  2. 2.Department of Pathology and Translational ResearchGifu University School of MedicineGifuJapan
  3. 3.Department of OtolaryngologyGifu University School of MedicineGifuJapan
  4. 4.Department of Oral and Maxillofacial SciencesGifu University School of MedicineGifuJapan

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