, Volume 59, Issue 9, pp 873–883 | Cite as

Natural history of lesions with the MR imaging appearance of multinodular and vacuolating neuronal tumor

  • Reema Alsufayan
  • Paula Alcaide-Leon
  • Lyne Noel de Tilly
  • Daniel M. Mandell
  • Timo KringsEmail author
Diagnostic Neuroradiology



Multinodular and vacuolating neuronal tumor (MVNT) have been recently added to the WHO classification of CNS tumors and has not been extensively reported upon in the radiological literature. We report the first radiological and the largest series of cases, aiming to highlight the natural history of lesions with the imaging appearance of MVNT with long follow-up time.


In this retrospective study, we collected cases with the imaging appearance of MVNT. All lesions were evaluated by using routine MR imaging, with follow-up of up to 93 months. Patient demographics, clinical course, and MRI features of the lesions were recorded.


Twenty-four subjects were enrolled, f/m = 16:8, age range 24–59 years, with a median age of 45 years. The patients’ symptoms were often episodic and most frequently due to headaches in 12 (50%), visual symptoms in 6 (25%), seizures in 5 ± 1 (20–25%), paresthesia in 4 (~17%), cognitive difficulties in 4 (~17%), in addition to other variable neurological symptoms, or incidental. A total of 30 lesions identified, 77% of the lesions had gadolinium-enhanced MRI and only 13% showed enhancement. A 6.7% of the lesions that had MRI followed up showed progression, while the rest remained stable up to 93 months interval. All patients had intact neurological examinations (except one case that was diagnosed with optic neuritis), were managed conservatively, and did well.


The natural history of lesions with imaging features of MVNT is overall stable from a clinical and imaging appearance over time.


Multinodular and vacuolating neuronal tumor (MVNT) Dysembryonic neuroepithelial tumor (DNET) Focal cortical dysplasia (FCD IIB) Virchow-Robin perivascular spaces (VRPS) 



Multinodular and vacuolating neuronal tumor


Periventricular white matter






Fluid attenuated inversion recovery


Computerized tomography


Weighted imaging


Dysembryonic neuroepithelial tumor


Focal cortical dysplasia


Virchow-Robin perivascular spaces


Compliance with ethical standards


No funding was received for this study.

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in the studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

Informed consent

The institutional review board waived informed consent from all individual participants included in the study.


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Copyright information

© Springer-Verlag GmbH Germany 2017

Authors and Affiliations

  1. 1.University of TorontoTorontoCanada
  2. 2.University of Toronto, St. Michael’s HospitalTorontoCanada
  3. 3.UHN Division of NeuroradiologyUniversity of Toronto, Toronto Western HospitalTorontoCanada

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