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Neuroradiology

, Volume 58, Issue 8, pp 771–775 | Cite as

Cervical spinal canal narrowing in idiopathic syringomyelia

  • Aaron F. Struck
  • Carrie M. Carr
  • Vinil Shah
  • John R. Hesselink
  • Victor M. Haughton
Diagnostic Neuroradiology

Abstract

Introduction

The cervical spine in Chiari I patient with syringomyelia has significantly different anteroposterior diameters than it does in Chiari I patients without syringomyelia. We tested the hypothesis that patients with idiopathic syringomyelia (IS) also have abnormal cervical spinal canal diameters. The finding in both groups may relate to the pathogenesis of syringomyelia.

Methods

Local institutional review boards approved this retrospective study. Patients with IS were compared to age-matched controls with normal sagittal spine MR. All subjects had T1-weighted spin-echo (500/20) and T2-weighted fast spin-echo (2000/90) sagittal cervical spine images at 1.5 T. Readers blinded to demographic data and study hypothesis measured anteroposterior diameters at each cervical level. The spinal canal diameters were compared with a Mann-Whitney U test. The overall difference was assessed with a Friedman test. Seventeen subjects were read by two reviewers to assess inter-rater reliability.

Results

Fifty IS patients with 50 age-matched controls were studied. IS subjects had one or more syrinxes varying from 1 to 19 spinal segments. Spinal canal diameters narrowed from C1 to C3 and then enlarged from C5 to C7 in both groups. Diameters from C2 to C4 were narrower in the IS group (p < 0.005) than in controls. The ratio of the C3 to the C7 diameters was also smaller (p = 0.004) in IS than controls. Collectively, the spinal canal diameters in the IS were significantly different from controls (Friedman test p < 0.0001).

Conclusion

Patients with IS have abnormally narrow upper and mid cervical spinal canal diameters and greater positive tapering between C3 and C7.

Keywords

Idiopathic syringomyelia Cerebrospinal fluid Cervical spinal canal CSF flow dynamics 

Abbreviations

IS

Idiopathic syringomyelia

ICC

Intra-class correlation coefficient

UW

University of Wisconsin

MC

Mayo Clinic

UCSF

University of California San Francisco

UCSD

University of California San Diego

CSF

Cerebrospinal fluid

IRB

Internal review board

SAS

Subarachnoid space

IQR

Interquartile range

Notes

Compliance with ethical standards

We declare that all human and animal studies have been approved by the respective internal review boards of Mayo Clinic, USA, University of California San Francisco, USA, University of California San Diego, USA, and the University of Wisconsin Madison, USA, and have therefore been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments. We declare that all patients gave informed consent prior to inclusion in this study.

Conflict of interest

We declare that we have no conflict of interest.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2016

Authors and Affiliations

  • Aaron F. Struck
    • 1
  • Carrie M. Carr
    • 2
  • Vinil Shah
    • 3
  • John R. Hesselink
    • 4
  • Victor M. Haughton
    • 5
  1. 1.Department of NeurologyMassachusetts General HospitalBostonUSA
  2. 2.Department of RadiologyMayo ClinicRochesterUSA
  3. 3.Department of RadiologyUniversity of California San FranciscoSan FranciscoUSA
  4. 4.Department of RadiologyUniversity of California San DiegoSan DiegoUSA
  5. 5.Department of RadiologyUniversity of WisconsinMadisonUSA

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