, Volume 57, Issue 11, pp 1135–1144 | Cite as

Arterial spin-labeling MR imaging of cerebral hemorrhages

  • Tomoyuki Noguchi
  • Masashi Nishihara
  • Yoshiaki Egashira
  • Shinya Azama
  • Tetsuyoshi Hirai
  • Isao Kitano
  • Yusuke Yakushiji
  • Masatou Kawashima
  • Hiroyuki Irie
Diagnostic Neuroradiology



The purpose of this study is to identify the characteristics of brain perfusion measured by arterial spin-labeling magnetic resonance imaging (ASL-MRI) in cerebral hemorrhages.


Brain blood flow values (CBF-ASL values) for cerebral and cerebellar hemispheres and segmented cerebral regions were measured by ASL-MRI in 19 putaminal hemorrhage patients and 20 thalamic hemorrhage patients in acute or subacute stages. We assessed the lateralities of CBF-ASL values and the relationships between CBF-ASL values and other imaging findings and clinical manifestations.


Both the 19 putaminal hemorrhage patients and the 20 thalamic hemorrhage patients had significantly low CBF-ASL values of the contralateral cerebellum in subacute stage, suggesting that ASL-MRI might delineate crossed cerebellar diaschisis (CCD). Ipsilateral low CBF-ASL values were observed in frontal lobes and thalami with a putaminal hemorrhage and lentiform nuclei, temporal lobes, and parietal lobes with a thalamic hemorrhage, suggesting that ASL-MRI showed the ipsilateral cerebral diaschisis (ICD). In the putaminal hemorrhage patients, the hematoma volume negatively affected both the bilateral cerebellar and cerebral hemispheric CBF-ASL values. In the thalamic hemorrhage patients, a concomitant intraventricular hemorrhage caused low cerebral hemispheric CBF-ASL values.


The use of ASL-MRI is sensitive to the perfusion abnormalities and could thus be helpful to estimate functional abnormalities in cerebral hemorrhage patients.


Arterial spin-labeling Brain perfusion Cerebral hemorrhage Putaminal hemorrhage Thalamic hemorrhage 



This work was partly supported by Grant-in-Aid for Scientific Research of Japan Society for the Promotion of Science.

Ethical standards and patient consent

We declare that all human and animal studies have been approved by the Institutional Review Board and have therefore been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments. We declare that the IRB waived written, informed consent.

Conflict of interest

We declare that we have no conflict of interest.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  • Tomoyuki Noguchi
    • 1
    • 2
  • Masashi Nishihara
    • 2
  • Yoshiaki Egashira
    • 2
  • Shinya Azama
    • 2
  • Tetsuyoshi Hirai
    • 2
  • Isao Kitano
    • 2
  • Yusuke Yakushiji
    • 3
  • Masatou Kawashima
    • 4
  • Hiroyuki Irie
    • 2
  1. 1.Department of Radiology, National Center for Global Health and MedicineTokyoJapan
  2. 2.Department of Radiology, Faculty of Medicine and Graduate School of MedicineSaga UniversitySagaJapan
  3. 3.Department of Neurology, Faculty of Medicine and Graduate School of MedicineSaga UniversitySagaJapan
  4. 4.Department of Neurosurgery, Faculty of Medicine and Graduate School of MedicineSaga UniversitySagaJapan

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