, Volume 56, Issue 12, pp 1079–1086 | Cite as

Thromboembolic events associated with single balloon-, double balloon-, and stent-assisted coil embolization of asymptomatic unruptured cerebral aneurysms: evaluation with diffusion-weighted MR imaging

  • Tomoji Takigawa
  • Kensuke Suzuki
  • Yoshiki Sugiura
  • Ryotaro Suzuki
  • Issei Takano
  • Nobuyuki Shimizu
  • Yoshihiro Tanaka
  • Akio Hyodo
Interventional Neuroradiology



The introduction of the balloon remodeling and stent-assisted technique has revolutionized the approach to coil embolization for wide-neck aneurysms. The purpose of this study was to determine the frequency of thromboembolic events associated with single balloon-assisted, double balloon-assisted, and stent-assisted coil embolization for asymptomatic unruptured aneurysms.


A retrospective review was undertaken by 119 patients undergoing coiling with an adjunctive technique for unruptured saccular aneurysms (64 single balloon, 12 double balloon, 43 stent assisted). All underwent diffusion-weighted imaging (DWI) within 24 h after the procedure.


DWI showed hyperintense lesions in 48 (40 %) patients, and ten (21 %) of these patients incurred neurological deterioration (permanent, two; transient, eight). Hyperintense lesions were detected significantly more often in procedures with the double balloon-assisted technique (7/12, 58 %) than with the single balloon-assisted technique (16/64, 25 %, p = 0.05). Occurrence of new lesions was significantly higher with the use of stent-assisted technique (25/43, 58 %) than with the single balloon-assisted technique (p = 0.001). Symptomatic ischemic rates were similar between the three groups. The increased number of microcatheters was significantly related to the DWI abnormalities (two microcatheters, 15/63 (23.8 %); three microcatheters, 20/41 (48.8 %) (p = 0.008); four microcatheters, 12/15 (80 %) (p = 0.001)).


Thromboembolic events detected on DWI related to coil embolization for unruptured aneurysms are relatively common, especially in association with the double balloon-assisted and stent-assisted techniques. Furthermore, the number of microcatheters is highly correlated with DWI abnormalities. The high rate of thromboembolic events suggests the need for evaluation of platelet reactivity and the addition or change of antiplatelet agents.


Unruptured aneurysm Coil embolization Balloon-assisted technique Stent-assisted technique Diffusion-weighted imaging 


Ethical standards and patient consent

We declare that all human and animal studies have been approved by the Ethical Review Board at Dokkyo Medical University Koshigaya Hospital, Koshigaya, Japan and have therefore been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments. We declare that all patients gave informed consent prior to inclusion in this study.

Conflict of interest

We declare that we have no conflict of interest.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Tomoji Takigawa
    • 1
  • Kensuke Suzuki
    • 1
  • Yoshiki Sugiura
    • 1
  • Ryotaro Suzuki
    • 1
  • Issei Takano
    • 1
  • Nobuyuki Shimizu
    • 1
  • Yoshihiro Tanaka
    • 1
  • Akio Hyodo
    • 1
  1. 1.Department of NeurosurgeryDokkyo Medical University Koshigaya HospitalKoshigayaJapan

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