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Neuroradiology

, Volume 56, Issue 7, pp 535–541 | Cite as

The extent of the perihemorrhagic perfusion zone correlates with hematoma volume in patients with lobar intracerebral hemorrhage

  • Kerim BeseogluEmail author
  • Nima Etminan
  • Bernd Turowski
  • Hans-Jakob Steiger
  • Daniel Hänggi
Diagnostic Neuroradiology

Abstract

Introduction

Existing data on perfusion imaging assumes the perihemorrhagic zone (PHZ) in patients with intracerebral hemorrhage (ICH) to be size steady. This study investigates the size of the perihemorrhagic zone (PHZ) in patients with lobar ICH in relation to hematoma volume during the course of treatment using perfusion CT (PCT).

Methods

The present analysis is based on a previously reported cohort of 20 patients undergoing surgical evacuation for lobar SICH, with pre- and early postoperative PCT scanning. Time to peak of the residue function (T max) was measured based on the 360° cortical banding method and singular value decomposition. The size of PHZ was determined before and after treatment and correlated with hematoma volume.

Results

Preoperative mean hematoma volume constituted 63.0 ml (interquartile ranges (IQR) 39.7–99.4 ml), which correlated significantly (r = 0.563, p = 0.010) with mean PHZ size (5.67 cm, IQR 5.44–8.17 cm). Following a surgical hematoma evacuation, mean hematoma volume was reduced to 2.5 ml IQR 0.0–9.5 ml, which also resulted in a significant reduction of PHZ size to 0.45 cm(IQR 0.0–1.36 cm; p < 0.001). There was no association between postoperative hematoma volume and size of the PHZ.

Conclusion

Our findings illustrate that the extent of the PHZ cannot be generally assumed to be constant in size and that this differs significantly following hematoma reduction in patients with space occupying lobar SICH.

Keywords

Intracerebral hemorrhage Perfusion CT Perihemorrhagic zone Evacuation 

Notes

Ethical standards and patient consent

We declare that all human and animal studies have been approved by the local ethics committee of the Medical Faculty of the Heinrich-Heine-University Düsseldorf, Germany, and have therefore been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments. We declare that all patients gave informed consent prior to inclusion in this study.

Conflict of interest

We declare that we have no conflict of interest.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Kerim Beseoglu
    • 1
    Email author
  • Nima Etminan
    • 1
  • Bernd Turowski
    • 2
  • Hans-Jakob Steiger
    • 1
  • Daniel Hänggi
    • 1
  1. 1.Department of Neurosurgery, Medical FacultyHeinrich-Heine-Universität DüsseldorfDüsseldorfGermany
  2. 2.Department of Diagnostic and Interventional Radiology, Medical FacultyHeinrich-Heine-Universität DüsseldorfDüsseldorfGermany

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