Motor function deficits in schizophrenia: an fMRI and VBM study
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To investigate whether the motor functional alterations in schizophrenia (SZ) are also associated with structural changes in the related brain areas using functional magnetic resonance imaging (fMRI) and voxel-based morphometry (VBM).
A sample of 14 right-handed SZ patients and 14 right-handed healthy control subjects matched for age, sex, and education were examined with structural high-resolution T1-weighted MRI; fMRI images were obtained during right index finger-tapping task in the same session.
fMRI results showed reduced functional activation in the motor areas (contralateral precentral and postcentral gyrus) and ipsilateral cerebellum in SZ subjects as compared to healthy controls (n = 14). VBM analysis also revealed reduced grey matter in motor areas and white matter reduction in cerebellum of SZ subjects as compared to controls.
The present study provides an evidence for a possible association between structural alterations in the motor cortex and disturbed functional activation in the motor areas in persons affected with SZ during a simple finger-tapping task.
KeywordsfMRI BOLD VBM Motor task Schizophrenia
This work was supported by DRDO R&D Project No. INM-311 (4.1) and funded in part by a grant to TB from the Fogarty International Center, NIH: The Impact of Yoga Supplementation on Cognitive Function Among Indian Outpatients Grant #1R01TW008289. Content is solely the author’s responsibility and does not necessarily represent the official views of the National Institutes of Health or other funding agencies.
Conflict of interest
We declare that we have no conflict of interest.
- 5.Karlsgodt KH, Glahn DC, van Erp TGM, Therman S, Huttunen M, Manninen M, Kaprio J, Cohen MS, Lönnqvist J, Cannon TD (2007) The relationship between performance and fMRI signal during working memory in patients with schizophrenia, unaffected co-twins, and control subjects. Schizophr Res 89:191–197PubMedCrossRefGoogle Scholar
- 8.Goldberg TE, Green MF (2002) Neurocognitive functioning in patients with schizophrenia: an overview. In: Davis KL, Charney D, Coyle JT, Nemeroff C (eds) Neuropsychopharmacology—fifth generation of progress. Lippincott, Philadelphia, pp 657–669Google Scholar
- 17.Wolff AL, O’Driscoll GA (1999) Motor deficits and schizophrenia: the evidence from neuroleptic-naive patients and populations at risk. J Psychiat Neurosci 24:304–314Google Scholar
- 22.Payoux P, Boulanouar K, Sarramon C, Fabre N, Descombes S, Galitsky M, Thalamas C, Brefel-Courbon C, Sabatini U, Manelfe C, Chollet F, Schmitt L, Rascol O (2004) Cortical motor activation in akinetic schizophrenic patients: a pilot functional MRI study. Mov Disord 19:83–90PubMedCrossRefGoogle Scholar
- 23.Ananth H, Popescu I, Critchley HD, Good CD, Frackowiak RS, Dolan RJ (2002) Cortical and subcortical gray matter abnormalities in schizophrenia determined through structural magnetic resonance imaging with optimized volumetric voxel based morphometry. Am J Psychiat 159(9):1497–1505PubMedCrossRefGoogle Scholar
- 24.Sigmundsson T, Suckling J, Maier M, Williams S, Bullmore E, Greenwood K, Fukuda R, Ron M, Toone B (2001) Structural abnormalities in frontal, temporal, and limbic regions and interconnecting white matter tracts in schizophrenic patients with prominent negative symptoms. Am J Psychiat 158(2):234–243PubMedCrossRefGoogle Scholar
- 26.Moorhead TW, Job DE, Whalley HC, Sanderson TL, Johnstone EC, Lawrie SM (2004) Voxel-based morphometry of comorbid schizophrenia and learning disability: analyses in normalized and native spaces using parametric and nonparametric statistical methods. Neuroimage 22(1):188–202PubMedCrossRefGoogle Scholar
- 29.Lui S, Deng W, Huang X, Jiang L, Ma X, Chen H, Zhang T, Li X, Li D, Zou L, Tang H, Zhou XJ, Mechelli A, C ollier DA, Sweeney JA, Li T, Gong Q (2009) Association of cerebral deficits with clinical symptoms in antipsychoticnaive first-episode schizophrenia: an optimized voxel-based morphometry and resting state functional connectivity study. Am J Psychiat 166:196–205PubMedCrossRefGoogle Scholar
- 30.Pomarol-Clotet E, Canales-Rodríguez EJ, Salvador R, Sarró S, Gomar JJ, Vila F, Ortiz-Gil J, Iturria-Medina Y, Capdevila A, McKenna PJ (2010) Medial prefrontal cortex pathology in schizophrenia as revealed by convergent findings from multimodal imaging. Mol Psychiat 15(8):823–830CrossRefGoogle Scholar
- 46.Joyce E, Hutton S, Mutsatsa S, Gibbins H, Webb E, Paul S, Robbins T, Barnes T (2002) Executive dysfunction in first-episode schizophrenia and relationship to duration of untreated psychosis: and relationship to duration of untreated psychosis: the West London Study. Br J Psychiat 181:s38–s44CrossRefGoogle Scholar