, Volume 56, Issue 5, pp 413–422 | Cite as

Motor function deficits in schizophrenia: an fMRI and VBM study

  • Sadhana Singh
  • Satnam Goyal
  • Shilpi Modi
  • Pawan Kumar
  • Namita Singh
  • Triptish Bhatia
  • Smita N. Deshpande
  • Subash Khushu
Functional Neuroradiology



To investigate whether the motor functional alterations in schizophrenia (SZ) are also associated with structural changes in the related brain areas using functional magnetic resonance imaging (fMRI) and voxel-based morphometry (VBM).


A sample of 14 right-handed SZ patients and 14 right-handed healthy control subjects matched for age, sex, and education were examined with structural high-resolution T1-weighted MRI; fMRI images were obtained during right index finger-tapping task in the same session.


fMRI results showed reduced functional activation in the motor areas (contralateral precentral and postcentral gyrus) and ipsilateral cerebellum in SZ subjects as compared to healthy controls (n = 14). VBM analysis also revealed reduced grey matter in motor areas and white matter reduction in cerebellum of SZ subjects as compared to controls.


The present study provides an evidence for a possible association between structural alterations in the motor cortex and disturbed functional activation in the motor areas in persons affected with SZ during a simple finger-tapping task.


fMRI BOLD VBM Motor task Schizophrenia 



This work was supported by DRDO R&D Project No. INM-311 (4.1) and funded in part by a grant to TB from the Fogarty International Center, NIH: The Impact of Yoga Supplementation on Cognitive Function Among Indian Outpatients Grant #1R01TW008289. Content is solely the author’s responsibility and does not necessarily represent the official views of the National Institutes of Health or other funding agencies.

Conflict of interest

We declare that we have no conflict of interest.

Supplementary material

234_2014_1325_Fig6_ESM.jpg (34 kb)
Fig. S1

Representative images of a raw data, b segmented grey matter, and c segmented white matter of a control subject (JPEG 34 kb)

234_2014_1325_Fig7_ESM.jpg (31 kb)

Representative images of a raw data, b segmented grey matter, and c segmented white matter of a schizophrenic subject (JPEG 30 kb)


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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Sadhana Singh
    • 1
  • Satnam Goyal
    • 2
  • Shilpi Modi
    • 1
  • Pawan Kumar
    • 1
  • Namita Singh
    • 1
  • Triptish Bhatia
    • 2
  • Smita N. Deshpande
    • 2
  • Subash Khushu
    • 1
  1. 1.NMR Research CenterInstitute of Nuclear Medicine and Allied Sciences (INMAS)DelhiIndia
  2. 2.PGIMERRML HospitalNew DelhiIndia

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