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Neuroradiology

, Volume 56, Issue 3, pp 177–186 | Cite as

High-resolution anatomy of the human brain stem using 7-T MRI: improved detection of inner structures and nerves?

  • Elke R. GizewskiEmail author
  • Stefan Maderwald
  • Jennifer Linn
  • Benjamin Dassinger
  • Katja Bochmann
  • Michael Forsting
  • Mark E. Ladd
Diagnostic Neuroradiology

Abstract

Introduction

The purpose of this paper is to assess the value of 7 Tesla (7 T) MRI for the depiction of brain stem and cranial nerve (CN) anatomy.

Methods

Six volunteers were examined at 7 T using high-resolution SWI, MPRAGE, MP2RAGE, 3D SPACE T2, T2, and PD images to establish scanning parameters targeted at optimizing spatial resolution. Direct comparisons between 3 and 7 T were performed in two additional subjects using the finalized sequences (3 T: T2, PD, MPRAGE, SWAN; 7 T: 3D T2, MPRAGE, SWI, MP2RAGE). Artifacts and the depiction of structures were evaluated by two neuroradiologists using a standardized score sheet.

Results

Sequences could be established for high-resolution 7 T imaging even in caudal cranial areas. High in-plane resolution T2, PD, and SWI images provided depiction of inner brain stem structures such as pons fibers, raphe, reticular formation, nerve roots, and periaqueductal gray. MPRAGE and MP2RAGE provided clear depiction of the CNs. 3D T2 images improved depiction of inner brain structure in comparison to T2 images at 3 T. Although the 7-T SWI sequence provided improved contrast to some inner structures, extended areas were influenced by artifacts due to image disturbances from susceptibility differences.

Conclusions

Seven-tesla imaging of basal brain areas is feasible and might have significant impact on detection and diagnosis in patients with specific diseases, e.g., trigeminal pain related to affection of the nerve root. Some inner brain stem structures can be depicted at 3 T, but certain sequences at 7 T, in particular 3D SPACE T2, are superior in producing anatomical in vivo images of deep brain stem structures.

Keywords

MRI 7 T Brain stem 

Notes

Acknowledgments

We would like to thank Lena Schäfer for assistance in scanning. We also thank the National Institutes of Health (NIH), Wellcome Trust and Howard Hughes Medical Institute (HHMI) for study funding.

Conflict of interest

We declare that we have no conflict of interest.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Elke R. Gizewski
    • 1
    Email author
  • Stefan Maderwald
    • 2
  • Jennifer Linn
    • 3
  • Benjamin Dassinger
    • 1
    • 4
  • Katja Bochmann
    • 3
  • Michael Forsting
    • 5
  • Mark E. Ladd
    • 2
    • 5
  1. 1.Department of NeuroradiologyMedical University InnsbruckInnsbruckAustria
  2. 2.Erwin L. Hahn Institute for Magnetic Resonance ImagingUniversity Duisburg-EssenEssenGermany
  3. 3.Department of NeuroradiologyLMU MunichMunichGermany
  4. 4.Department of NeuroradiologyJustus-Liebig-University GiessenGiessenGermany
  5. 5.Departments of Diagnostic and Interventional Radiology and NeuroradiologyUniversity Hospital, University Duisburg-EssenEssenGermany

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