Spinal cord stimulation modulates cerebral neurobiology: a proton magnetic resonance spectroscopy study
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Although spinal cord stimulation (SCS) is a widely used treatment for chronic neuropathic pain secondary to spinal surgery, little is known about the underlying physiological mechanisms.
The primary aim of this study is to investigate the neural substrate underlying short-term SCS by means of 1H MR spectroscopy with short echo time, in 20 patients with failed back surgery syndrome.
Marked increase of γ-aminobutyric acid (GABA) and decrease in glucose in the ipsilateral thalamus were found between baseline situation without SCS and after 9′ of SCS, indicating the key role of the ipsilateral thalamus as a mediator of chronic neuropathic pain. In addition, this study also showed a progressive decrease in glucose in the ipsilateral thalamus over time, which is in line with the findings of previous studies reporting deactivation in the ipsilateral thalamic region.
The observation of GABA increase and glucose decrease over time in the ipsilateral thalamus may be the causal mechanism of the pain relief due to SCS or an epiphenomenon.
KeywordsSpinal cord stimulator Proton magnetic resonance spectroscopy GABA Thalamus
We thank Ursule Van de Velde and Cindy Tettelin for their help in data management.
Conflict of interest
MM is a clinical investigator of The Research Foundation Flanders (FWO) and received the Lyrica Independent Investigator Research Award (LIIRA); he has received consultancy or speaker honoraria from Medtronic and Pfizer. RB has received consultancy or speaker honoraria from Pfizer, Medtronic, Shire Human Genetics Therapies, Sanofi-Aventis and Bayer. BN has received grants for research, education, and travel from Medtronic Inc, and holds a Chair for Neurosurgery for Psychiatric Disorders, funded by a donation from Medtronic Inc.; he has received grants from OT, FWO, IWT-3WIN, and SBO.
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