, Volume 54, Issue 12, pp 1303–1312 | Cite as

Future trials of endovascular mechanical recanalisation therapy in acute ischemic stroke patients - A position paper endorsed by ESMINT and ESNR

Part II: methodology of future trials
  • Jens Fiehler
  • Michael Söderman
  • Francis Turjman
  • Philip M. White
  • Søren Jacob Bakke
  • Salvatore Mangiafico
  • Rüdiger von Kummer
  • Mario Muto
  • Christophe Cognard
  • Jan Gralla
Invited Review


Based on current data and experience, the joint working group of the European Society of Minimally Invasive Neurological Therapy (ESMINT) and the European Society of Neuroradiology (ESNR) make suggestions on trial design and conduct aimed to investigate therapeutic effects of mechanical thrombectomy (MT). We anticipate that this roadmap will facilitate the setting up and conduct of successful trials in close collaboration with our neighbouring disciplines.


Stroke Interventional neuroradiology Thrombectomy Thrombolysis 



Alberta Stroke Program Early CT


Balloon guiding catheter occlusion


Best medical therapy


Carotid stenting


Cerebral blood flow


Cerebral blood volume


Common carotid artery


Carotid endarterectomy


Conscious sedation






Digital subtraction angiography


Diffusion weighted imaging


Early ischemic signs


European Society of Minimally Invasive Neurological Therapy


European Society of Neuroradiology


European Stroke Organisation


Follow up


General anaesthesia


Internal carotid artery


Interventional Management of Stroke III Trial


Intravenous thrombolytical therapy


Middle cerebral artery


Modified rankin scale


Mechanical thrombectomy


Non-enhanced CT


National Institute of Health Stroke Scale


Perfusion MRI


Randomised control trial


Symptomatic intracranial haemorrhage


Self-expanding stents


Conflict of interest

JF consults for Stryker and Codman, and gives presentations to Covidien, Boehringer Ingelheim, Philips and Siemens MS has a Consultant agreement with Mindframe (now owned by Covidien) and is PI for the Rapid Medical study. FT consults for Stryker and Codman, is on the Codman Board, and has a proctoring agreement and holds workshops for Covidien. RVK receives personal compensation for serving on the Advisory Board of Lundbeck AC, serves as Co-Chair on the Steering Committee of the DIAS-3 and -4 trials, serves on the image adjudication committee for these trials and consults for Synarc; he is Section Editor, Interventional Neuroradiology, of the journal Neuroradiology. MM is a consultant for Synthes, AB Medica/Italy, gives presentations for Johnson & Johnson and has research support from ActiveO. CC consults for Covidien, Stryker, Codman and Microvention. JG is PI of the STAR Study (Covidien).


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Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  • Jens Fiehler
    • 1
  • Michael Söderman
    • 2
  • Francis Turjman
    • 3
  • Philip M. White
    • 4
  • Søren Jacob Bakke
    • 5
  • Salvatore Mangiafico
    • 6
  • Rüdiger von Kummer
    • 7
  • Mario Muto
    • 8
  • Christophe Cognard
    • 9
  • Jan Gralla
    • 10
  1. 1.Department of NeuroradiologyUniversity Medical Centre Hamburg-EppendorfHamburgGermany
  2. 2.Department of NeuroradiologyKarolinska University HospitalStockholmSweden
  3. 3.Department of NeuroradiologyHôpital neurologique, Centre de Neurosciences CognitivesLyonFrance
  4. 4.Department of Clinical Neurosciences, Western General HospitalUniversity of EdinburghEdinburghUK
  5. 5.Department of NeuroradiologyOslo University HospitalOsloNorway
  6. 6.Interventional Neuroradiology UnitUniversity Hospital CareggiFlorenceItaly
  7. 7.Department of NeuroradiologyUniversity of DresdenDresdenGermany
  8. 8.Department of NeuroradiologyUniversity of NaplesNaplesItaly
  9. 9.Service de NeuroradiologieHôpital PurpanToulouseFrance
  10. 10.Department of NeuroradiologyInselspital BernBernSwitzerland

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