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Neuroradiology

, Volume 54, Issue 10, pp 1171–1178 | Cite as

Short-term evolution of spinal cord damage in multiple sclerosis: a diffusion tensor MRI study

  • M. ThéaudinEmail author
  • G. Saliou
  • B. Ducot
  • K. Deiva
  • C. Denier
  • D. Adams
  • D. Ducreux
Functional Neuroradiology

Abstract

Introduction

The potential of diffusion tensor imaging (DTI) to detect spinal cord abnormalities in patients with multiple sclerosis has already been demonstrated. The objective of this study was to apply DTI techniques to multiple sclerosis patients with a recently diagnosed spinal cord lesion, in order to demonstrate a correlation between variations of DTI parameters and clinical outcome, and to try to identify DTI parameters predictive of outcome.

Methods

A prospective single-centre study of patients with spinal cord relapse treated by intravenous steroid therapy was made. Patients were assessed clinically and by conventional MRI with DTI sequences at baseline and at 3 months.

Results

Sixteen patients were recruited. At 3 months, 12 patients were clinically improved. All but one patient had lower fractional anisotropy (FA) and apparent diffusion coefficient (ADC) values than normal subjects in either inflammatory lesions or normal-appearing spinal cord. Patients who improved at 3 months presented a significant reduction in the radial diffusivity (p = 0.05) in lesions during the follow-up period. They also had a significant reduction in the mean ADC (p = 0.002), axial diffusivity (p = 0.02), radial diffusivity (p = 0.02) and a significant increase in FA values (p = 0.02) in normal-appearing spinal cord. Patients in whom the American Spinal Injury Association sensory score improved at 3 months showed a significantly higher FA (p = 0.009) and lower radial diffusivity (p = 0.04) in inflammatory lesion at baseline compared to patients with no improvement.

Conclusion

DTI MRI detects more extensive abnormalities than conventional T2 MRI. A less marked decrease in FA value and more marked decreased in radial diffusivity inside the inflammatory lesion were associated with better outcome.

Keywords

Spinal cord DTI Fractional anisotropy Multiple sclerosis Outcome measurement 

Notes

Conflict of interest

We declare that we have no conflict of interest.

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Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  • M. Théaudin
    • 1
    • 2
    Email author
  • G. Saliou
    • 3
  • B. Ducot
    • 4
  • K. Deiva
    • 5
  • C. Denier
    • 1
    • 2
  • D. Adams
    • 1
    • 2
  • D. Ducreux
    • 2
    • 3
  1. 1.Service de Neurologie AdultesAP-HP, CHU BicêtreLe Kremlin-BicêtreFrance
  2. 2.Faculté de Médecine Paris SudINSERM, UMR788Le Kremlin-BicêtreFrance
  3. 3.Service de NeuroradiologieAP-HP, CHU BicêtreLe Kremlin-BicêtreFrance
  4. 4.CESP Centre for Research in Epidemiology and Population Health, Faculté de Médecine Paris SudINSERM, U1018Le Kremlin-BicêtreFrance
  5. 5.Service de NeuropédiatrieLe Kremlin-BicêtreFrance

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