Neuroradiology

, Volume 54, Issue 10, pp 1145–1152

Italian multicenter experience with flow-diverter devices for intracranial unruptured aneurysm treatment with periprocedural complications—a retrospective data analysis

  • Francesco Briganti
  • Manuela Napoli
  • Fabio Tortora
  • Domenico Solari
  • Mauro Bergui
  • Edoardo Boccardi
  • Enrico Cagliari
  • Lucio Castellan
  • Francesco Causin
  • Elisa Ciceri
  • Luigi Cirillo
  • Roberto De Blasi
  • Luigi Delehaye
  • Francesco Di Paola
  • Andrea Fontana
  • Roberto Gasparotti
  • Giulio Guidetti
  • Ignazio Divenuto
  • Giuseppe Iannucci
  • Maurizio Isalberti
  • Marco Leonardi
  • Fernando Lupo
  • Salvatore Mangiafico
  • Andrea Manto
  • Roberto Menozzi
  • Mario Muto
  • Nunzio Paolo Nuzzi
  • Rosario Papa
  • Benedetto Petralia
  • Mariangela Piano
  • Maurizio Resta
  • Riccardo Padolecchia
  • Andrea Saletti
  • Giovanni Sirabella
  • Luca Piero Valvassori Bolgè
Interventional Neuroradiology

DOI: 10.1007/s00234-012-1047-3

Cite this article as:
Briganti, F., Napoli, M., Tortora, F. et al. Neuroradiology (2012) 54: 1145. doi:10.1007/s00234-012-1047-3

Abstract

Introduction

We report the experiences of 25 Italian centers, analyzing intra- and periprocedural complications of endovascular treatment of intracranial aneurysms using Silk (Balt Extrusion, Montmorency, France) and pipeline embolization devices (EV3 Inc, Irvine California).

Methods

Two hundred seventy-three patients with 295 cerebral aneurysms, enrolled in 25 centers in Italy and treated with the new flow-diverter devices, were evaluated; 142 patients were treated with Silk and 130 with pipeline (in one case, both devices were used). In 14 (5.2 %) cases devices were used with coils. Aneurysm size was >15 mm in 46.9 %, 5–15 mm in 42.2 %, and <5 mm in 10.8 %. Aneurysm locations were supraclinoid internal carotid artery (ICA) in 163 cases (55.2 %), cavernous ICA in 76 (25.7 %), middle cerebral artery in 11 (3.7 %), PCoA in 6 (2 %), and ACoA in 2 (0.7 %); the vertebrobasilar system accounted for 32 cases (10.8 %) and PCA in 5 (1.7 %).

Results

Technical adverse events occurred with 59 patients (21.6 %); 5 patients died after ischemic events, 10 to hemorrhagic complications, and 1 from external ventricular drain positioning. At 1 month, morbidity and mortality rates were 3.7 % and 5.9 %, respectively

Conclusion

Our retrospective study confirms that morbidity and mortality rates in treatment with FDD of unruptured wide-neck or untreatable cerebral aneurysms do not differ from those reported in the largest series.

Keywords

Flow diverter device Pipeline embolization device Silk embolization device Intracranial aneurysms Endovascular treatment 

Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  • Francesco Briganti
    • 1
  • Manuela Napoli
    • 1
  • Fabio Tortora
    • 2
  • Domenico Solari
    • 3
  • Mauro Bergui
    • 4
  • Edoardo Boccardi
    • 5
  • Enrico Cagliari
    • 6
  • Lucio Castellan
    • 7
  • Francesco Causin
    • 8
  • Elisa Ciceri
    • 9
  • Luigi Cirillo
    • 10
  • Roberto De Blasi
    • 11
  • Luigi Delehaye
    • 12
  • Francesco Di Paola
    • 13
  • Andrea Fontana
    • 14
  • Roberto Gasparotti
    • 15
  • Giulio Guidetti
    • 16
  • Ignazio Divenuto
    • 17
  • Giuseppe Iannucci
    • 18
  • Maurizio Isalberti
    • 19
  • Marco Leonardi
    • 10
  • Fernando Lupo
    • 20
  • Salvatore Mangiafico
    • 21
  • Andrea Manto
    • 22
  • Roberto Menozzi
    • 23
  • Mario Muto
    • 24
  • Nunzio Paolo Nuzzi
    • 25
  • Rosario Papa
    • 19
  • Benedetto Petralia
    • 26
  • Mariangela Piano
    • 5
  • Maurizio Resta
    • 27
  • Riccardo Padolecchia
    • 28
  • Andrea Saletti
    • 29
  • Giovanni Sirabella
    • 30
  • Luca Piero Valvassori Bolgè
    • 5
  1. 1.Interventional Neuroradiology Unit“Federico II” UniversityNaplesItaly
  2. 2.Institute of RadiologySecond University of NapoliNaplesItaly
  3. 3.Division of Neurosurgery“Federico II” UniversityNaplesItaly
  4. 4.Neuroradiology DivisionUniversity of TorinoTurinItaly
  5. 5.Interventional Neuroradiology DivisionNiguarda HospitalMilanItaly
  6. 6.Neuroradiology UnitOspedale dell’AngeloMestreItaly
  7. 7.Department of NeuroradiologySan Martino HospitalGenovaItaly
  8. 8.Neuroradiology DivisionCity HospitalVicenzaItaly
  9. 9.Neuroradiology UnitFondazione IRCCS Istituto Neurologico “Carlo Besta”MilanItaly
  10. 10.Department of NeuroradiologyBellaria-Maggiore HospitalBolognaItaly
  11. 11.Unit of Neuroradiology and Interventional RadiologyUniversity HospitalBariItaly
  12. 12.Unit of NeuroradiologySan Giovanni Bosco HospitalNaplesItaly
  13. 13.Department of NeuroradiologyTreviso HospitalTrevisoItaly
  14. 14.Unit of BiostatisticsIRCCS “Casa Sollievo della Sofferenza”San Giovanni RotondoItaly
  15. 15.Institute of NeuroradiologyUniversity of Brescia, Ospedali CiviliBresciaItaly
  16. 16.Neuroradiology, School of MedicineUniversity of Rome “La Sapienza”RomeItaly
  17. 17.Department of Radiology“Amedeo Avogadro” UniversityNovaraItaly
  18. 18.Department of NeuroradiologyVicenza HospitalVicenzaItaly
  19. 19.Diagnostic and Interventional NeuroradiologyFondazione IRCCS Ca` Granda, Ospedale Maggiore PoliclinicoMilanItaly
  20. 20.Department of Neuroradiology“V. Fazzi” HospitalLecceItaly
  21. 21.Department of NeuroradiologyCareggi HospitalFlorenceItaly
  22. 22.Department of Neuroradiology“Umberto I” HospitalNocera InferioreItaly
  23. 23.Department of NeuroradiologyUniversity of ParmaParmaItaly
  24. 24.Neuroradiology Unit“A. Cardarelli” HospitalNaplesItaly
  25. 25.Unit of Diagnostic and Interventional NeuroradiologyE.O. Ospedali GallieraGenovaItaly
  26. 26.Department of NeuroradiologyUdine University HospitalUdineItaly
  27. 27.Department of Radiology and Neuroradiology“SS. Annunziata” HospitalTarantoItaly
  28. 28.Neuroradiology Unit“Santa Corona” HospitalPietra LigureItaly
  29. 29.Neuroradiology Unit“S. Anna” HospitalFerraraItaly
  30. 30.Neuroradiology Unit“Loreto Nuovo” HospitalNaplesItaly

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