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Neuroradiology

, Volume 54, Issue 7, pp 681–689 | Cite as

Detecting damaged regions of cerebral white matter in the subacute phase after carbon monoxide poisoning using voxel-based analysis with diffusion tensor imaging

  • Shunrou Fujiwara
  • Takaaki BeppuEmail author
  • Hideaki Nishimoto
  • Katsumi Sanjo
  • Atsuhiko Koeda
  • Kiyoshi Mori
  • Kohsuke Kudo
  • Makoto Sasaki
  • Kuniaki Ogasawara
Diagnostic Neuroradiology

Abstract

Introduction

The present study aimed to detect the main regions of cerebral white matter (CWM) showing damage in the subacute phase for CO-poisoned patients with chronic neurological symptoms using voxel-based analysis (VBA) with diffusion tensor imaging (DTI).

Methods

Subjects comprised 22 adult CO-poisoned patients and 16 age-matched healthy volunteers as controls. Patients were classified into patients with transient acute symptoms only (group A) and patients with chronic neurological symptoms (group S). In all patients, DTI covering the whole brain was performed with a 3.0-T magnetic resonance imaging system at 2 weeks after CO exposure. As procedures for VBA, all fractional anisotropy (FA) maps obtained from DTI were spatially normalized, and FA values for all voxels in the whole CWM on normalized FA maps were statistically compared among the two patient groups and controls.

Results

Voxels with significant differences in FA were detected at various regions in comparisons between groups S and A and between group S and controls. In these comparisons, more voxels were detected in deep CWM, including the centrum semiovale, than in other regions. A few voxels were detected between group A and controls. Absolute FA values in the centrum semiovale were significantly lower in group S than in group A or controls.

Conclusions

VBA demonstrated that CO-poisoned patients with chronic neurological symptoms had already suffered damage to various CWM regions in the subacute phase. In these regions, the centrum semiovale was suggested to be the main region damaged in the subacute phase after CO inhalation.

Keywords

CO poisoning Diffusion tensor imaging Fractional anisotropy Myelin basic protein Voxel-based analysis 

Notes

Acknowledgments

This study was supported in part by Grant-in-Aid for Scientific Research C (no. 22592020) and grants for the Strategic Medical Science Research Center for Advanced Medical Science Research from the Ministry of Science, Education, Sports and Culture, Japan.

Conflict of interest

We declare that we have no conflict of interest.

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Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • Shunrou Fujiwara
    • 1
  • Takaaki Beppu
    • 1
    • 2
    Email author
  • Hideaki Nishimoto
    • 1
  • Katsumi Sanjo
    • 3
  • Atsuhiko Koeda
    • 3
  • Kiyoshi Mori
    • 4
  • Kohsuke Kudo
    • 5
  • Makoto Sasaki
    • 5
  • Kuniaki Ogasawara
    • 1
  1. 1.Department of NeurosurgeryIwate Medical UniversityMoriokaJapan
  2. 2.Department of Hyperbaric MedicineIwate Medical UniversityMoriokaJapan
  3. 3.Department of PsychiatryIwate Medical UniversityMoriokaJapan
  4. 4.Department of NeurologyIwate Prefectural Critical Care and Emergency CenterMoriokaJapan
  5. 5.Advanced Medical Research CenterIwate Medical UniversityMoriokaJapan

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