, Volume 54, Issue 1, pp 5–12 | Cite as

Brain atrophy and lesion load are related to CSF lipid-specific IgM oligoclonal bands in clinically isolated syndromes

  • Maria José MagranerEmail author
  • Isabel Bosca
  • Maria Simó-Castelló
  • Gracian García-Martí
  • Angel Alberich-Bayarri
  • Francisco Coret
  • Jose C. Álvarez-Cermeño
  • Luís Martí-Bonmatí
  • Luisa M. Villar
  • Bonaventura Casanova
Diagnostic Neuroradiology



The objective of this work is to study the relationship between the presence of lipid-specific oligoclonal IgM bands (LS-OCMB) in CSF, with both T2 lesion volume (T2LV) accumulation and brain atrophy (percentage change of brain volume–PCBV–and brain parenchyma fraction–BPF) in patients with clinically isolated syndromes (CIS) suggestive of demyelination.


Twenty-four CIS patients were included in this prospective study. IgG oligoclonal bands (OCGB) and LS-OCMB were determined in paired serum and CSF samples within 3 months since clinical onset. Brain MRI studies were scheduled at baseline, 3 months, first and second years after CIS onset. Differences in T2LV, PCBV and BPF between CIS patients according to the type of OCB were studied.


Nine patients had no OCB; 15 had only OCGB, and seven had OCGB + LS-OCMB present in the CSF. LS-OCMB were associated with greater T2LV in all scheduled MRI studies. At the end of follow-up (year 2), it was threefold higher in patients with these antibodies than in those without LS-OCMB (3.95 cm3 vs. 1.36 cm3, p = 0.001). At that point, brain atrophy was also higher in patients with LS-OCMB (BPF, 0.73 in LS-OCMB+ patients vs. 0.76 in negative ones, p = 0.03). The rate in brain atrophy was higher in the first group of patients as well. Considering only patients with OCGB, the presence of LS-OCMB was also related to greater T2LV, T2LV increase and a trend towards higher atrophy rate.


The presence of LS-OCMB in the first event suggestive of demyelination is related to an early increase in lesion load and brain atrophy. These data are in line with prospective studies showing the clinical prognostic value of LS-OCMB.


Multiple sclerosis Clinically isolated syndrome Magnetic resonance imaging IgM oligoclonal bands 



This work has been performed with the financial support from the following national projects: FIS PI060822, FIS PS09/00551, PS09/01652 and PS09/01338 from the Carlos III Institute from Spain. The authors also thank nurses of the MS units (Matilde Escutia and Ana Bernal) and D. Carpio and B. Ovalle for their excellent technical assistance.

Conflict of interest

We declare that we have no conflict of interest.


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Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • Maria José Magraner
    • 1
    Email author
  • Isabel Bosca
    • 1
  • Maria Simó-Castelló
    • 1
  • Gracian García-Martí
    • 2
    • 6
  • Angel Alberich-Bayarri
    • 2
  • Francisco Coret
    • 3
  • Jose C. Álvarez-Cermeño
    • 4
  • Luís Martí-Bonmatí
    • 2
  • Luisa M. Villar
    • 5
  • Bonaventura Casanova
    • 1
  1. 1.Multiple Sclerosis Unit, Neurology DepartmentHospital La FeValenciaSpain
  2. 2.Magnetic Resonance UnitHospital QuirónValenciaSpain
  3. 3.Multiple Sclerosis Unit, Neurology DepartmentHospital Clinic UniversitariValenciaSpain
  4. 4.Neurology DepartmentHospital Ramón y CajalMadridSpain
  5. 5.Immunology DepartmentHospital Ramón y CajalMadridSpain
  6. 6.CIBER Mental Health Network, ISCIIIValenciaSpain

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