, Volume 53, Issue 1, pp 43–48 | Cite as

Measurements of the normal fetal brain at gestation weeks 17 to 23: a MRI study

  • Nuno Canto Moreira
  • João Teixeira
  • Raquel Themudo
  • Hashem Amini
  • Ove Axelsson
  • Raili Raininko
  • Johan Wikstrom
Paediatric Neuroradiology



To obtain measurements of the normal fetal brain before 24 weeks of gestation (GW), a deadline for medical decisions on fetal viability in a large number of countries.


We retrospectively reviewed 70 normal MR examinations of fetuses aged GW 17 to 23. The fronto-occipital diameter, the cerebral bi-parietal diameter, the transverse cerebellar diameter, the vermian height, and antero-posterior diameter were measured.


The median, maximum, and minimum values for each parameter were displayed for each individual GW.


The recorded data might contribute to a better assessment of fetal health by providing normal boundaries for the brain growth.


Fetal Biometry Brain Normal development MRI 


Conflicts of interest

We declare that we have no conflict of interest.


  1. 1.
    Levine D, Barnes PD, Robertson RR, Wong G, Mehta TS (2003) Fast MR imaging of fetal central nervous system abnormalities. Radiology 229(1):51–61. doi: 10.1148/radiol.2291020770 CrossRefPubMedGoogle Scholar
  2. 2.
    Whitby EH, Paley MN, Sprigg A et al (2004) Comparison of ultrasound and magnetic resonance imaging in 100 singleton pregnancies with suspected brain abnormalities. BJOG 111(8):784–792. doi: 10.1111/j.1471-0528.2004.00149.x CrossRefPubMedGoogle Scholar
  3. 3.
    Timor-Tritsch IE, Monteagudo A, Cohen HL (2001) Ultrasonography of the prenatal and neonatal brain. McGraw-Hill, Health Professions Division, New YorkGoogle Scholar
  4. 4.
    Pilu G, Nicolaides KH (1999) Diagnosis of fetal abnormalities: the 18–23-week scan. Parthenon, New YorkGoogle Scholar
  5. 5.
    Guihard-Costa AM, Larroche JC (1992) Growth velocity of some fetal parameters. I. Brain weight and brain dimensions. Biol Neonate 62(5):309–316CrossRefPubMedGoogle Scholar
  6. 6.
    Guihard-Costa AM, Larroche JC, Droulle P, Narcy F (1995) Fetal biometry. Growth charts for practical use in fetopathology and antenatal ultrasonography. Introduction. Fetal Diagn Ther 10(4):211–278CrossRefPubMedGoogle Scholar
  7. 7.
    Tilea B, Alberti C, Adamsbaum C et al (2009) Cerebral biometry in fetal magnetic resonance imaging: new reference data. Ultrasound Obstet Gynecol 33(2):173–181. doi: 10.1002/uog.6276 CrossRefPubMedGoogle Scholar
  8. 8.
    Reichel TF, Ramus RM, Caire JT, Hynan LS, Magee KP, Twickler DM (2003) Fetal central nervous system biometry on MR imaging. AJR Am J Roentgenol 180(4):1155–1158PubMedGoogle Scholar
  9. 9.
    Garel C (2004) The role of MRI in the evaluation of the fetal brain with an emphasis on biometry, gyration and parenchyma. Pediatr Radiol 34(9):694–699. doi: 10.1007/s00247-004-1249-x CrossRefPubMedGoogle Scholar
  10. 10.
    Garel C (2005) Fetal cerebral biometry: normal parenchymal findings and ventricular size. Eur Radiol 15(4):809–813. doi: 10.1007/s00330-004-2610-z CrossRefPubMedGoogle Scholar
  11. 11.
    Parazzini C, Righini A, Rustico M, Consonni D, Triulzi F (2008) Prenatal magnetic resonance imaging: brain normal linear biometric values below 24 gestational weeks. Neuroradiology 50(10):877–883. doi: 10.1007/s00234-008-0421-7 CrossRefPubMedGoogle Scholar
  12. 12.
    Garel C (2004) MRI of the fetal brain. Normal development and cerebral pathologies. Springer, BerlinGoogle Scholar
  13. 13.
  14. 14.
    Watanabe Y, Abe S, Takagi K, Yamamoto T, Kato T (2005) Evolution of subarachnoid space in normal fetuses using magnetic resonance imaging. Prenat Diagn 25(13):1217–1222. doi: 10.1002/pd.1315 CrossRefPubMedGoogle Scholar
  15. 15.
    Goldstein I, Reece EA, Pilu G, Bovicelli L, Hobbins JC (1987) Cerebellar measurements with ultrasonography in the evaluation of fetal growth and development. Am J Obstet Gynecol 156(5):1065–1069. doi: 0002-9378(87)90111-6 PubMedGoogle Scholar
  16. 16.
    Hill LM, Guzick D, Fries J, Hixson J, Rivello D (1990) The transverse cerebellar diameter in estimating gestational age in the large for gestational age fetus. Obstet Gynecol 75(6):981–985PubMedGoogle Scholar
  17. 17.
    Griffiths PD, Wilkinson ID, Variend S, Jones A, Paley MN, Whitby E (2004) Differential growth rates of the cerebellum and posterior fossa assessed by post mortem magnetic resonance imaging of the fetus: implications for the pathogenesis of the chiari 2 deformity. Acta Radiol 45(2):236–242CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Nuno Canto Moreira
    • 1
    • 2
  • João Teixeira
    • 3
  • Raquel Themudo
    • 2
  • Hashem Amini
    • 4
  • Ove Axelsson
    • 4
  • Raili Raininko
    • 2
  • Johan Wikstrom
    • 2
  1. 1.Neuroradiology Section C. Campos CostaPortoPortugal
  2. 2.Department of RadiologyUppsala UniversityUppsalaSweden
  3. 3.Department of NeuroradiologyH. G. S. AntonioPortoPortugal
  4. 4.Department of Women’s and Children’s HealthUppsala UniversityUppsalaSweden

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