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Neuroradiology

, Volume 52, Issue 12, pp 1185–1191 | Cite as

Functional MRI of tongue motor tasks in patients with tongue cancer: observations before and after partial glossectomy

  • Samantha Haupage
  • Kyung K. PeckEmail author
  • Ryan C. Branski
  • Meier Hsu
  • Andrei Holodny
  • Dennis Kraus
Functional Neuroradiology

Abstract

Introduction

The current study seeks to provide preliminary data regarding this central, adaptive response during tongue motor tasks utilizing functional magnetic resonance imaging (fMRI) before and after glossectomy.

Methods

Six patients, with confirmed histological diagnoses of oral tongue cancer, underwent fMRI before and 6 months after partial glossectomy. These data were compared to nine healthy controls. All subjects performed three tongue motor tasks during fMRI: tongue tapping (TT), dry swallow (Dry), and wet swallow (Wet).

Results

Following surgery, increased activation was subjectively observed in the superior parietal lobule, supplementary motor area, and anterior cingulate. Region of interest (ROI) analysis of the precentral gyrus confirmed increased cortical activity following surgery. In addition, comparisons between pre-surgical scans and controls suggested the dry swallow task was sensitive to elicit tongue-related activation in the precentral gyrus (p ≤ 0.05).

Conclusions

The adaptive changes in the cortex following partial glossectomy reflect recruitment of the parietal, frontal, and cingulate cortex during tongue motor tasks. In addition, post-operative activation patterns more closely approximated control levels than the pre-operative scans. Furthermore, the dry swallow task appears most specific to elicit tongue-related cortical activity.

Keywords

Tongue cancer Functional MRI Cortical adaptation Swallowing Glossectomy 

Notes

Acknowledgements

The study was funded by Hackers for Hope, the Langeloth Foundation, and the Garban Fund.

Conflict of interest statement

We declare that we have no conflict of interest.

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Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Samantha Haupage
    • 1
  • Kyung K. Peck
    • 2
    • 3
    • 5
    Email author
  • Ryan C. Branski
    • 1
  • Meier Hsu
    • 4
  • Andrei Holodny
    • 2
  • Dennis Kraus
    • 1
  1. 1.Head & Neck SurgeryMemorial Sloan-Kettering Cancer CenterNew YorkUSA
  2. 2.Department of RadiologyMemorial Sloan-Kettering Cancer CenterNew YorkUSA
  3. 3.Medical PhysicsMemorial Sloan-Kettering Cancer CenterNew YorkUSA
  4. 4.Department of Epidemiology and BiostatisticsMemorial Sloan-Kettering Cancer CenterNew YorkUSA
  5. 5.Department of Medical Physics and RadiologyMemorial Sloan-Kettering Cancer CenterNew YorkUSA

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