, Volume 52, Issue 6, pp 489–494 | Cite as

Hippocampal development at gestation weeks 23 to 36. An ultrasound study on preterm neonates

  • Dragan Bajic
  • Uwe Ewald
  • Raili Raininko
Topic Article



During fetal development, the hippocampal structures fold around the hippocampal sulcus into the temporal lobe. According to the literature, this inversion should be completed at gestation week (GW) 21. Thereafter, the hippocampal shape should resemble the adult shape. However, incomplete hippocampal inversion (IHI) is found in 19% of the common population. The aim of this study was to study fetal hippocampal development by examining neonates born preterm.


We analyzed cranial ultrasound examinations, performed as a part of the routine assessment of all preterm infants, over a 3-year period and excluded the infants with brain pathology. The final material consisted of 158 children born <35 GW. A rounded form (the ratio between the horizontal and vertical diameters of the hippocampal body ≤1) in coronal slices was considered the sign of IHI.


The age at examination was 23–24 GW in 24 neonates, 25–28 GW in 70 neonates, and 29-36 GW in 64 neonates. IHI was found in 50%, 24%, and 14%, respectively. The difference between the neonates <25 GW and ≥25 GW was statistically highly significant (p < 0.001). The frequency of bilateral IHI was highest in the youngest age group. In the other groups, the left-sided IHI was the most common.


In about 50% of the neonates, hippocampal inversion is not completed up to GW 24; but from 25 GW onwards, the frequency and laterality of IHI is similar to that in the adult population.


Fetal development Ultrasonography Hippocampus Premature infants Gestational age Malrotation 


Conflict of interest statement

We declare that we have no conflict of interest.


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Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  1. 1.Department of Radiology, University HospitalUppsala UniversityUppsalaSweden
  2. 2.Department of Women’s and Children’s HealthUppsala UniversityUppsalaSweden

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